I Spy in the Developing Fly a Multitude of Ways to Die.

Journal of Developmental Biology
Alla YalonetskayaKimberly McCall

Abstract

Cell proliferation and cell death are two opposing, yet complementary fundamental processes in development. Cell proliferation provides new cells, while developmental programmed cell death adjusts cell numbers and refines structures as an organism grows. Apoptosis is the best-characterized form of programmed cell death; however, there are many other non-apoptotic forms of cell death that occur throughout development. Drosophila is an excellent model for studying these varied forms of cell death given the array of cellular, molecular, and genetic techniques available. In this review, we discuss select examples of apoptotic and non-apoptotic cell death that occur in different tissues and at different stages of Drosophila development. For example, apoptosis occurs throughout the nervous system to achieve an appropriate number of neurons. Elsewhere in the fly, non-apoptotic modes of developmental cell death are employed, such as in the elimination of larval salivary glands and midgut during metamorphosis. These and other examples discussed here demonstrate the versatility of Drosophila as a model organism for elucidating the diverse modes of programmed cell death.

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Citations

Jul 10, 2019·Cell Death and Differentiation·Alla YalonetskayaKimberly McCall
Aug 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gianluca Tettamanti, Morena Casartelli
Nov 21, 2019·Cell Death and Differentiation·Tianqi XuSharad Kumar
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Taylor D HinnantElizabeth T Ables
Oct 20, 2020·Current Opinion in Insect Science·David MartínXavier Franch-Marro

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Methods Mentioned

BETA
electron microscopy

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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