I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets

Pharmaceutics
Patricija JanuskaiteAlvaro Goyanes

Abstract

3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing. The paediatric population presents a variety of pharmaceutical formulation challenges such as dose flexibility, patient compliance, taste masking and the fear or difficulty to swallow tablets, all factors that could be overcome using the adaptable nature of 3DP. User acceptability studies of 3D printed formulations have been previously carried out in adults; however, feedback from children themselves is essential in establishing the quality target product profile towards the development of age-appropriate medicines. The aim of this study was to investigate the preference of children for different 3D printed tablets (Printlets™) as an important precursor to patient acceptability studies. Four different 3DP technologies; digital light processing (DLP), selective laser sintering (SLS), semi-solid extrusion (SSE) and fused deposition modeling (FDM) were used to prepare placebo printlets with similar physical attributes including size and shape. A single-site, two-part survey was completed with participants aged 4-11 years to determine their preference and opinions based on visual...Continue Reading

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Citations

Mar 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Iria Seoane-ViañoAlvaro Goyanes
Mar 12, 2021·Advanced Drug Delivery Reviews·Jhinuk Rahman, Julian Quodbach
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May 10, 2021·Advanced Drug Delivery Reviews·Iria Seoane-ViañoAlvaro Goyanes
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May 21, 2021·Advanced Drug Delivery Reviews·Christine M MadlaAbdul W Basit
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Sep 15, 2021·Expert Opinion on Drug Delivery·Sujit Kumar DebnathAbdelwahab Omri

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Software Mentioned

SPSS Statistics
Kudo3D Print Job
Sintratec
Excel
Makerware

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