I₂-TBHP-catalyzed oxidative cross-coupling of N-sulfonyl hydrazones and isocyanides to 5-aminopyrazoles

Organic Letters
Gopal Chandru SenadiJeh-Jeng Wang

Abstract

I2-TBHP-catalyzed oxidative cross coupling of N-sulfonyl hydrazones with isocyanides has been realized for the synthesis of 5-aminopyrazoles through formal [4 + 1] annulation via in situ azoalkene formation. Notable features are the metal/alkyne-free strategy, C-C and C-N bond formation, atom economy, catalytic I2, broad functional group tolerance, good reaction yields, shorter time, and also applicability to one-pot methodology.

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Citations

Mar 24, 2016·Chemical Communications : Chem Comm·Guojiao WuJianbo Wang
Nov 9, 2017·Organic & Biomolecular Chemistry·Balakrishna Aegurla, Rama Krishna Peddinti
Oct 7, 2016·Chemical Communications : Chem Comm·Gopal Chandru SenadiJeh-Jeng Wang
Mar 30, 2017·Chemical Society Reviews·Ying Xia, Jianbo Wang

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