PMID: 6406641Jun 1, 1983Paper

Ia antigens in rat kidney, with special reference to their expression in tubular epithelium

The Journal of Experimental Medicine
G Mayrhofer, M A Schon-Hegrad

Abstract

The distribution of Ia antigens in rat kidneys has been investigated by an immunoperoxidase technique, using monoclonal antibodies directed at framework determinants on molecules equivalent to gene products of the I-A and I-E/C regions of the mouse major histocompatibility complex (MHC). Antigens mapping to both loci were detected in proximal convoluted tubule epithelium and on scattered dendritic cells in the interstitial connective tissues, glomeruli, and mucosa of the renal pelvis. All other structures were negative. Genetic studies indicate that the levels of expression of Ia molecules from both genetic loci are controlled by non-MHC genes in epithelium, but not on lymphocytes. The subcellular distribution of Ia molecules has been investigated in tubular epithelium and is discussed in relation to their possible functions in epithelia.

References

Jan 1, 1976·The Journal of Experimental Medicine·C DavidD Shreffler
Jan 1, 1979·Scandinavian Journal of Immunology·U ForsumP A Peterson
Jan 1, 1979·Scandinavian Journal of Immunology·B CurmanP A Peterson
Jun 1, 1979·European Journal of Immunology·W R McMaster, A F Williams
Dec 14, 1978·Nature·K WimanP A Peterson
Oct 1, 1978·European Journal of Immunology·D W Mason, G G Gallico
Aug 1, 1969·The Journal of Cell Biology·M E Beard, A B Novikoff
Oct 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F PignalG Feldmann
Oct 1, 1982·Allergy·O Werdelin
Jun 1, 1981·The Journal of Experimental Medicine·A N Barclay, G Mayrhofer
Jan 1, 1980·Scandinavian Journal of Immunology·H ScottE Thorsby
Jan 1, 1981·Transplantation·P G NataliS Ferrone
Sep 1, 1981·Tissue Antigens·H ScottE Thorsby
Jan 1, 1980·Scandinavian Journal of Immunology·P HäyryL C Andersson
Apr 1, 1960·The Journal of Biophysical and Biochemical Cytology·S J HOLTG L PAWAN

❮ Previous
Next ❯

Citations

Jan 1, 1990·Anatomy and Embryology·B Sundelin, S O Bohman
Jun 1, 1988·Immunology Today·P Bland
May 20, 1998·Research in Immunology·L Mayer
Nov 1, 1986·The Journal of Experimental Medicine·D LeszczynskiP Häyry
Apr 27, 1996·Transplantation·B T HeelanA J George
Nov 1, 1986·Kidney International·P VerroustF Chatelet
Jan 1, 1988·Kidney International·A A Eddy, A F Michael
Aug 1, 1989·Kidney International·P M MattilaP J Häyry
Aug 1, 1986·Journal of Immunogenetics·T CrepaldiD F Antczak
Jan 1, 1993·International Reviews of Immunology·D T Hagerty, P M Allen
Mar 27, 2003·Nature Reviews. Immunology·Matthias G von Herrath, Leonard C Harrison
Apr 25, 2019·American Journal of Physiology. Renal Physiology·Philippe Christophe BredaKatrin Neumann
May 1, 1986·European Journal of Immunology·F MomburgG J Hämmerling
Oct 1, 1988·Human Pathology·G AndresF Cavalot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.