Ia-bearing cells promote the concanavalin A mitogenic response of Ia-negative T cells

European Journal of Immunology
J A Frelinger

Abstract

Nylon wool column-purified T cell populations depleted of Ia-bearing cells do not respond to the T cell mitogen concanavalin A (Con A). The response of this population can be restored by admixture of untreated nylon wool-nonadherent T cells. These promotor cells express Thy-1, are not sensitive to mitomycin C treatment and cannot be replaced with adherent spleen cells. Experiments using the T6 chromosome marker demonstrate that Ia-depleted populations respond to ConA only in the presence of the Ia-positive population.

References

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Citations

Jan 1, 1979·Scandinavian Journal of Immunology·A R Rivas AlcalaM F Filosa
Jan 1, 1978·Immunological Reviews·U PerssonC I Smith
Jan 1, 1978·Scandinavian Journal of Immunology·U PerssonC I Smith
Jan 1, 1980·Immunological Reviews·R T SmithY Konaka
Jan 1, 1984·Cellular Immunology·P R Morrow, H Abplanalp
May 1, 1991·European Journal of Immunology·R T TregearW T Mason

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