PMID: 2497621Jan 1, 1989Paper

Ia-expressing microglial cells in experimental allergic encephalomyelitis in rats

Acta Neuropathologica
H KonnoH Terunuma

Abstract

Monoclonal antibodies (MRC OX-6 and OX-17) recognized three types of cells expressing Ia antigen during the course of acute experimental allergic encephalomyelitis (EAE) in rats. In earlier stages of the disease, in animals with or without paralysis, Ia antigens were mostly localized to subarachnoidal and perivascular lymphocytic and histiocytic cell infiltrates, possibly serving as antigen-presenting cells. On the other hand, in convalescent rats, Ia antigens were expressed in a large number of cells with dendritic processes heavily populating the spinal gray matter. The appearance of these Ia-expressing cells in the convalescent stage coincided with the development of degenerating axon terminals in the spinal gray matter. These Ia-expressing cells possessed morphological features characteristic of microglia and were positive for ML-1 lectin but did not express glial fibrillary acidic protein. Immune electron microscopy disclosed the presence of Ia reaction products in the Golgi apparatus, endoplasmic reticulum and plasma membrane of these cells with dendritic processes, indicating active synthesis of Ia molecules in microglia. In addition, Ia antigens were localized to the cells with ultrastructural features of macrophages. T...Continue Reading

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Citations

Oct 12, 2001·Glia·H Neumann
Jan 1, 1993·Glia·R B BanatiG W Kreutzberg
Dec 1, 1989·Journal of Neuroimmunology·H KonnoH Terunuma
Dec 1, 1991·Journal of Neuroimmunology·T Morioka, W J Streit
Dec 1, 1994·Journal of Neuroimmunology·K ImamuraT Marunouchi
Apr 9, 1999·Journal of Neurotrauma·T WatanabeH Kayama
Feb 1, 1992·Neuropathology and Applied Neurobiology·A Sasaki, Y Nakazato
Oct 1, 1995·Neuropathology and Applied Neurobiology·C KaurE A Ling
Aug 10, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Helena BatoulisStefanie Kuerten
Sep 21, 2007·Journal of Neuropathology and Experimental Neurology·Sarah M McKayElspeth M McLachlan
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B BanatiG W Kreutzberg
Jul 21, 1998·Brain Pathology·R EgenspergerM B Graeber

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