IAP regulation of metastasis.

Cancer Cell
Swarna MehrotraDario C Altieri

Abstract

Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis. This pathway is independent of IAP inhibition of cell death. Instead, a survivin-XIAP complex activates NF-kappaB, which in turn leads to increased fibronectin gene expression, signaling by beta1 integrins, and activation of cell motility kinases FAK and Src. Therefore, IAPs are direct metastasis genes, and their antagonists could provide antimetastatic therapies in patients with cancer.

References

May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G SannaR J Ulevitch
Sep 10, 1999·The Journal of Biological Chemistry·J K SlackJ T Parsons
May 16, 2000·The Journal of Biological Chemistry·R Hofer-WarbinekR de Martin
Sep 7, 2001·Current Opinion in Cell Biology·S M Frisch, R A Screaton
Sep 5, 2002·Nature Reviews. Cancer·Suzanne Cory, Jerry M Adams
Sep 17, 2002·Current Opinion in Cell Biology·Edna CukiermanKenneth M Yamada
Jan 1, 2004·The Journal of Biological Chemistry·Jennifer LewisColin S Duckett
May 26, 2004·Biochemical Society Transactions·R L JulianoA Aplin
Jun 2, 2004·Nature Reviews. Cancer·Timothy J Yeatman
Jun 26, 2004·The Journal of Biological Chemistry·Takehiko DohiDario C Altieri
May 4, 2005·Cancer Research·Whitney SalzDario C Altieri
Jul 15, 2005·Cell Death and Differentiation·D E BredesenS Rabizadeh
Aug 2, 2005·Nature Reviews. Cancer·Britta WeigeltLaura J van 't Veer
Aug 16, 2005·Current Opinion in Cell Biology·Mark H GinsbergSanford J Shattil
Sep 20, 2005·Cancer Cell·Matthew J PaszekValerie M Weaver
Dec 21, 2005·The Journal of Cell Biology·Hanna Y IrieJoan S Brugge
Jan 7, 2006·Nature·Dwayne G StupackDavid A Cheresh
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Celeste M Nelson, Mina J Bissell
Aug 22, 2006·Current Opinion in Cell Biology·Satyajit K Mitra, David D Schlaepfer
Sep 9, 2006·The Journal of Investigative Dermatology·Cédric GaggioliSophie Tartare-Deckert
Apr 19, 2007·Nature Reviews. Genetics·Don X Nguyen, Joan Massagué
Jul 7, 2007·Molecular Cell·Takehiko DohiDario C Altieri
Dec 14, 2007·Nature Reviews. Cancer·Dario C Altieri
Dec 20, 2007·Cancer Research·James E Talmadge
Dec 20, 2007·Cancer Research·Christina ScheelRobert A Weinberg
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·J Thomas ParsonsW Gregory Roberts
Mar 7, 2008·Apoptosis : an International Journal on Programmed Cell Death·Véronique BouchardPierre H Vachon
May 3, 2008·Cancer Research·Courtney M WilliamsJean E Schwarzbauer
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jozien HellemanEls M J J Berns
Nov 18, 2008·Nature Cell Biology·Taner DoganKrishnaraj Rajalingam
Jul 9, 2009·Journal of Cell Science·Ulrike ReschRainer de Martin

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Citations

Jun 7, 2013·Journal of Bone and Mineral Metabolism·Chang Yang, Deborah Veis Novack
Apr 17, 2013·Apoptosis : an International Journal on Programmed Cell Death·Sun Hee ParkSteven M Frisch
Jan 12, 2012·Current Oncology Reports·David N Church, Denis C Talbot
Sep 7, 2013·Cell Death & Disease·T K Oberoi-KhanujaK Rajalingam
Jul 24, 2010·Nature Reviews. Cancer·Mads Gyrd-Hansen, Pascal Meier
Feb 23, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jessica PlatiRoya Khosravi-Far
Jan 23, 2013·The Cancer Journal·Robert R ZielinskiKim N Chi
Jun 4, 2011·Molekuliarnaia biologiia·A V KnizhnikI B Zborovskaia
Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Christoph S NabzdykMichael S Conte
Nov 1, 2011·Cancer Research·Christina M Medina-RamirezRichard N Kitsis
Mar 3, 2011·The Journal of Clinical Investigation·Markus D SiegelinDario C Altieri
Aug 8, 2013·The Journal of Clinical Investigation·M Cecilia CainoDario C Altieri
Aug 26, 2010·BMC Cancer·Bruno MassiddaGiuseppe Palmieri
May 23, 2012·Diagnostic Pathology·Xiaopeng CaiXinyu Zheng
Apr 8, 2011·World Journal of Gastroenterology : WJG·Anastasia PavlidouKleanthi Dimas
Apr 24, 2012·ISRN Oncology·Arthur W LambertSam Thiagalingam
Oct 17, 2013·Carcinogenesis·Nora I HippChristian Beltinger

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