IAPs and cell migration

Seminars in Cell & Developmental Biology
Laurence Dubrez, Krishnaraj Rajalingam

Abstract

Inhibitors of apoptosis (IAPs) constitute a family of cell signaling regulators controlling several fundamental biological processes such as innate immunity, inflammation, cell death, cell proliferation, and cell differentiation. Increasing evidence from in vivo and in vitro studies indicate a function for IAPs in the modulation of invasive and migratory properties of cells. Here, we present and discuss the mechanisms whereby IAPs can control cell migration.

References

Feb 9, 1996·Cell·D A Lauffenburger, A F Horwitz
Feb 28, 2002·Molecular and Cellular Biology·M Germana SannaRichard J Ulevitch
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Jun 26, 2004·The Journal of Biological Chemistry·Takehiko DohiDario C Altieri
Oct 31, 2006·PLoS Pathogens·Krishnaraj RajalingamThomas Rudel
Dec 18, 2007·Molecular Cell·Lei XuJunying Yuan
Feb 9, 2008·Cell Death and Differentiation·C HwangC S Duckett
Jul 16, 2008·International Journal of Oral and Maxillofacial Surgery·S QiK Omura
Nov 6, 2008·Cell·Victoria Sanz-MorenoChristopher J Marshall
Nov 18, 2008·Nature Cell Biology·Taner DoganKrishnaraj Rajalingam
Jun 6, 2009·Journal of Cell Science·Sam J MathewMaria Leptin
Nov 17, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·T-S WangP Liu
Dec 3, 2009·The Journal of Cell Biology·Peter Friedl, Katarina Wolf
Feb 5, 2010·Cancer Cell·Swarna MehrotraDario C Altieri
Apr 20, 2010·Nature Cell Biology·Etienne BoulterKeith Burridge
Jul 27, 2010·Biochemical and Biophysical Research Communications·Sunyoung Ahn, Heonyong Park
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian D FingasGregory J Gores
Mar 12, 2011·The Journal of Biological Chemistry·Rebecca FelthamCatherine L Day
Apr 26, 2011·Cellular Signalling·Kristy Stengel, Yi Zheng
Jun 21, 2011·Small GTPases·Etienne Boulter, Rafael Garcia-Mata
Jun 24, 2011·Nature Reviews. Molecular Cell Biology·Domagoj VucicIngrid E Wertz
Jul 23, 2011·Nature Reviews. Molecular Cell Biology·Rafael Garcia-MataKeith Burridge
Nov 1, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Etienne BoulterChloé C Féral
Feb 7, 2012·Molecular Cell·Alison J HansonEthan Lee
Jul 14, 2012·Small GTPases·Tripat Kaur Oberoi-Khanuja, Krishnaraj Rajalingam
Sep 7, 2013·Cell Death & Disease·T K Oberoi-KhanujaK Rajalingam
Oct 5, 2013·OncoTargets and Therapy·Laurence DubrezValérie Glorian
Nov 28, 2013·Cellular and Molecular Life Sciences : CMLS·Arun Murali, Krishnaraj Rajalingam
Dec 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael C HornburgerRobert Fürst
Jul 1, 2014·The EMBO Journal·Armelle-Natsuo TakedaKrishnaraj Rajalingam
Jul 30, 2014·Seminars in Cell & Developmental Biology·Simone Fulda

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Citations

Oct 23, 2019·Cellular and Molecular Life Sciences : CMLS·Qiuyun JiangCeshi Chen
May 6, 2020·Cells·Baptiste DumétierLaurence Dubrez
Feb 19, 2019·Oxidative Medicine and Cellular Longevity·Paulina Gil-KulikJanusz Kocki
Oct 6, 2017·American Journal of Physiology. Cell Physiology·Travis LearYuan Liu
Nov 13, 2020·The FEBS Journal·Camila Castillo FerrerGabriel Ichim
Feb 23, 2020·Acta Pharmaceutica Sinica. B·Yang WangHaopeng Sun
Jun 26, 2020·Pharmacology & Therapeutics·Swati KumarRichard C Turkington

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