IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

Nature Reviews. Cancer
Mads Gyrd-Hansen, Pascal Meier

Abstract

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis, as well as cell invasion and metastasis.

References

Apr 29, 1994·Science·K WhiteH Steller
Apr 1, 1993·Journal of Virology·N E CrookL K Miller
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·A G UrenD L Vaux
Jul 17, 1997·Nature·Q L DeverauxJ C Reed
May 9, 1998·The Journal of Biological Chemistry·R TakahashiJ C Reed
Jun 6, 1998·The Journal of Experimental Medicine·D VercammenP Vandenabeele
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C J HawkinsB A Hay
Jul 15, 1999·Nature Structural Biology·M G HindsC L Day
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 17, 2000·The EMBO Journal·P MeierG I Evan
Aug 22, 2000·The Journal of Biological Chemistry·S M SrinivasulaE S Alnemri
Mar 21, 2001·Cell·J ChaiP Dataa
Mar 21, 2001·Cell·S J RiedlG S Salvesen
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·D ConteR G Korneluk
Apr 21, 2001·Molecular and Cellular Biology·H HarlinC B Thompson
May 18, 2001·The Journal of Biological Chemistry·S Birkey ReffeyC S Duckett
Apr 19, 2002·Nature·Arie J van Noordwijk
May 22, 2002·Nature Cell Biology·Soon Ji YooBruce A Hay
Nov 21, 2002·The Journal of Biological Chemistry·Tom Vanden BerghePeter Vandenabeele
Mar 7, 2003·Molecular Cell·Eric N ShiozakiYigong Shi
Mar 7, 2003·Molecular Cell·Kelly M BoatrightGuy S Salvesen
Apr 15, 2003·Nature Cell Biology·Mark DitzelPascal Meier
Jun 19, 2003·Molecular and Cellular Neurosciences·Thorsten TrappDan Lindholm

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Citations

Nov 22, 2013·Molecular Pharmaceutics·Laura GattiPaola Perego
Oct 12, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sharon CohenEliezer Flescher
May 3, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aristeidis G VaiopoulosAthanasios G Papavassiliou
Feb 2, 2013·Seminars in Immunopathology·María Laura GabelloniJorge Geffner
Jan 22, 2013·Apoptosis : an International Journal on Programmed Cell Death·Octavio A GonzalezJeffrey L Ebersole
Oct 12, 2012·Journal of Mammary Gland Biology and Neoplasia·Shaomeng WangHaiying Sun
May 7, 2011·Targeted Oncology·Jennifer S CarewSteffan T Nawrocki
Aug 3, 2012·Cell Reports·Lorenzo GalluzziGuido Kroemer
Sep 3, 2013·Journal of Biotechnology·Varsha P Wadegaonkar, Prasad A Wadegaonkar
Sep 13, 2011·ACS Combinatorial Science·Sebastian T Le QuementThomas E Nielsen
Oct 1, 2011·Cell Death and Differentiation·T KaufmannP J Jost
Nov 19, 2011·Cell Death and Differentiation·M Darding, P Meier
Sep 29, 2012·Cell Death and Differentiation·A E ChristiansenA Bergmann
Apr 15, 2011·Cell Death & Disease·H H CheungR G Korneluk
Jul 13, 2013·Cell Death & Disease·A D BadleyS R Lewin
Sep 7, 2013·Cell Death & Disease·T K Oberoi-KhanujaK Rajalingam
Aug 4, 2011·Nature Communications·Xiaochun LiYigong Shi
Jan 20, 2011·Nature Immunology·Thomas A Kufer, Philippe J Sansonetti
Feb 4, 2012·Nature Reviews. Drug Discovery·Lorenzo GalluzziGuido Kroemer
Feb 23, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jessica PlatiRoya Khosravi-Far
Sep 8, 2012·Molecular BioSystems·Éder Maiquel SimãoJosé Carlos Merino Mombach
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christy C OngKlaus P Hoeflich
Aug 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiko ArimaKoh-Ichiro Yoshiura
Jun 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Konstantin I PiatkovAlexander Varshavsky
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ting-Chun Yeh, Shawn B Bratton
Oct 20, 2010·The Journal of Biological Chemistry·Herman H CheungRobert G Korneluk
Aug 19, 2011·The Journal of Biological Chemistry·Yide MeiXiaolu Yang
Feb 16, 2012·The Journal of Biological Chemistry·Byeong-Gu HanByung Il Lee

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