Jun 12, 2018

Iatrogenic Creutzfeldt-Jakob disease

Handbook of Clinical Neurology
Atsushi KobayashiHidehiro Mizusawa

Abstract

Iatrogenic transmission of Creutzfeldt-Jakob disease (CJD) has occurred through particular medical procedures. Among them, dura mater grafts and pituitary-derived growth hormone obtained from human cadavers undiagnosed as CJD are the most frequent sources of infection. Recent advances in our knowledge about dura mater graft- and human pituitary-derived growth hormone-associated CJD patients have revealed that the combination of the infected CJD strain and the PRNP genotype of the patient determines their clinical, neuropathologic, and biochemical features. In this chapter, we summarize the clinical, neuropathologic, biochemical, and diagnostic features of dura mater graft- and human pituitary-derived growth hormone-associated CJD patients for the appropriate diagnosis of iatrogenic CJD.

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Mentioned in this Paper

New Variant Creutzfeldt-Jakob Disease
Growth Hormone Activity
Pituitary Diseases
Brain
Cadaver
Neuropathology
Dura Mater
Disease Transmission
Pituitary Hormonal Agents
Growth Hormone Measurement

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