PMID: 9440165Jan 1, 1997Paper

Iatrogenic limbal stem cell deficiency

Transactions of the American Ophthalmological Society
Edward J Holland, G S Schwartz

Abstract

To describe a group of patients with limbal stem cell (SC) deficiency without prior diagnosis of a specific disease entity known to be causative of SC deficiency. We performed a retrospective review of the records of all patients with ocular surface disease presenting to the University of Minnesota between 1987 and 1996. Patients were categorized according to etiology of limbal deficiency. Patients who did not have a specific diagnosis previously described as being causative for limbal deficiency were analyzed. Risk factors, clinical findings and sequelae were evaluated. Eight eyes of six patients with stem cell deficiency not secondary to a known diagnosis were described. All eyes had prior ocular surgery involving the corneoscleral limbus. Six eyes had been on chronic topical medications and all eyes had concurrent external disease such as pterygium, keratoconjunctivitis sicca, rosacea or herpes simplex virus keratitis. All eyes had superior quadrants affected corresponding to areas of prior limbal surgery. Sequelae of disease included corneal scarring and neo-vascularization, and five eyes had with visual acuity of 20/200 or worse. Because the epitheliopathy started peripherally and extended centrally in all patients, we fee...Continue Reading

Citations

Apr 27, 2004·Experimental Eye Research·Robert M LavkerTung-Tien Sun
Nov 5, 2002·Ophthalmology·Edgar M EspanaScheffer C G Tseng
Jul 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Hall F Chew
Nov 12, 2016·American Journal of Ophthalmology·Swathi KalikiVirender S Sangwan

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