IκB-kinase-ε in the tumor microenvironment is essential for the progression of gastric cancer

Oncotarget
Biao GengQiang You

Abstract

The tumor microenvironment is critical for tumor growth and metastasis, but the underlying molecular mechanisms are poorly understood. Recent studies have shown that IκB-kinase-ε (IKKε) is involved in the proliferation and migration of certain cancers. However, the functional role of IKKε in the progression of gastric cancer (GC) remains unknown. In this study, we found that high levels of IKKε expression in GC tumors were correlated with more advanced disease and poor overall survival of patients. Silencing of IKKε effectively suppressed the migratory and invasive capabilities of human GC cells in vitro and tumorigenicity and metastasis in vivo. Further analysis revealed that IKKε was also highly expressed in tumor-infiltrating lymphocytes. Moreover, it was involved in tumor-infiltrating T-cell-mediated invasion and metastasis. Knockdown of IKKε elevated T-cell antitumor immunity. These findings suggest that IKKε may be a novel prognostic marker and a potential therapeutic target in human GCs.

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Citations

Jan 24, 2019·Biomarkers in Medicine·Ziba Nariman-Saleh-FamJavad Tavakkoli-Bazzaz
Nov 17, 2019·Cancer Medicine·Min YinJie Lu
Nov 7, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y LiuQ Huang

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Methods Mentioned

BETA
bronchoalveolar lavage
xenograft
xenografts
chips
bronchoalveolar
flow cytometry

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