Abstract
Over the past three decades, changes to the chemical structures of the bisphosphonates have resulted in progressive improvements in their antiresorptive potencies. Ibandronate is a potent, nitrogen-containing bisphosphonate that possesses a tertiary nitrogen group on its R2 side chain and a hydroxyl group on its R1 side chain, which together confer one of the highest antiresorptive potencies of all bisphosphonates. In common with other nitrogen-containing bisphosphonates, ibandronate is a strong inhibitor of farnesyl pyrophosphate synthase, which probably accounts for its major effects on osteoclast activity. In addition, it binds strongly to hydroxyapatite. The pharmacological efficacy and safety of various continuous and intermittent regimens of ibandronate have been extensively investigated in experimental models of osteoporosis in several animal species, including rats, dogs, and monkeys. In ovariectomized (OVX) rats, intermittent (dosing interval 2, 4, and 6 weeks) and continuous ibandronate regimens provided equivalent results per total dose irrespective of the dosing regimen. Similar results were obtained in OVX dogs and monkeys. High doses of ibandronate many times those used therapeutically were well tolerated and did ...Continue Reading
References
Jan 1, 1970·Calcified Tissue Research·R G RussellH Fleisch
Sep 19, 1969·Science·H FleischM D Francis
Jan 1, 1983·Calcified Tissue International·H ShinodaP Hagan
Oct 1, 1994·The Biochemical Journal·M J RogersD J Watts
Dec 1, 1993·The Journal of Clinical Investigation·R BalenaD Frankenfield
Oct 1, 1993·Calcified Tissue International·J A GuyW C Hayes
Jul 17, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S LallaF Bauss
Jul 28, 1999·Bone·R G Russell, M J Rogers
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R G RussellM J Rogers
Nov 24, 1999·The Journal of Clinical Investigation·L I PlotkinT Bellido
Jun 2, 2001·The New England Journal of Medicine·K L Sauder
Jan 13, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Stephen F HodgsonUNKNOWN AACE Osteoporosis Task Force
Jun 19, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Frieder Bauss, R Graham G Russell
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles H ChesnutUNKNOWN Oral Ibandronate Osteoporosis Vertebral Fracture Trial in North America and Europe (BONE)
Jul 6, 2004·Journal of Pharmacological and Toxicological Methods·Frieder BaussGisbert Sponer
Oct 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ralph MüllerFrieder Bauss
Dec 14, 2004·The Journal of Biological Chemistry·Lilian I PlotkinTeresita Bellido
Jun 7, 2005·Bone·A H A KurthF Bauss
Citations
Dec 11, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J E M BrouwersM L Bouxsein
Aug 21, 2008·Calcified Tissue International·Julienne E M BrouwersMary L Bouxsein
Jan 19, 2016·Nature Chemical Biology·Feifei ChenLefu Lan
Jul 21, 2010·Biomaterials·Elise VerronJean-Michel Bouler
Jul 6, 2010·Fitoterapia·L M F LucindaM O Guerra
Mar 27, 2007·Journal of Pharmaceutical and Biomedical Analysis·J A Bertinatto RodríguezL E Diaz
Nov 10, 2006·Bone·Yu ZhengColin R Dunstan
Oct 22, 2008·Oral Diseases·D StefanikS O Akintoye
Mar 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dick Ho-Kiu ChowWing-Hoi Cheung
Oct 9, 2015·Yonsei Medical Journal·Yoon Sok ChungTaeyong Lee
May 15, 2012·Molecular and Cellular Endocrinology·Masanobu TsubakiShozo Nishida
Apr 11, 2020·Journal of Biomedical Materials Research. Part a·Ethan M LotzZvi Schwartz