IBD considerations in spondyloarthritis

Therapeutic Advances in Musculoskeletal Disease
Caroline Di Jiang, Tim Raine

Abstract

Spondyloarthritis (SpA) may be regarded a family of auto-inflammatory conditions with inflammation focused on the joints. These form part of a wider family of immune-mediated inflammatory diseases, which include inflammatory bowel diseases (IBD). These conditions share common elements of pathophysiology and it is perhaps unsurprising, therefore, that individuals with SpA frequently manifest gastrointestinal inflammation, to which the physician managing the patient with SpA must be alert. In this article, we review the shared epidemiology and pathophysiology of these conditions, before discussing approaches to diagnosis and management of inflammatory gastrointestinal pathology in patients seen in rheumatology clinics. In particular, we discuss the difference between non-specific gastrointestinal inflammation commonly described in this patient group and the more specific diagnosis of Crohn's disease or ulcerative colitis. We describe the appropriate diagnostic workup for patients suspected of having IBD. In addition, we discuss how a diagnosis of IBD can inform treatment selection, highlighting important differences in treatment choice, drug dosing, monitoring and drug safety for this particular comorbid patient population.

References

Jan 1, 1988·British Journal of Rheumatology·H MielantsM de Vos
May 1, 1981·Postgraduate Medical Journal·D S Rampton, G E Sladen
Jan 1, 1994·Arthritis and Rheumatism·M Leirisalo-RepoK Seppälä
Jan 1, 1997·Scandinavian Journal of Rheumatology·Y H LeeG G Song
Jan 5, 2002·Gastroenterology Clinics of North America·J L Wallace
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
Dec 13, 2005·The New England Journal of Medicine·Paul RutgeertsJean Frédéric Colombel
Feb 14, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·William J SandbornBradley J Bloom
Jul 20, 2007·The New England Journal of Medicine·William J SandbornUNKNOWN PRECISE 1 Study Investigators
Jul 20, 2007·The New England Journal of Medicine·Stefan SchreiberUNKNOWN PRECISE 2 Study Investigators
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Apr 11, 2012·Nature Reviews. Rheumatology·John D Reveille
Nov 10, 2012·Annals of the Rheumatic Diseases·Liesbet Van PraetDirk Elewaut
Dec 13, 2012·Gut·Jean Frédéric ColombelDaniel Poulain
Mar 5, 2013·Insights Into Imaging·Carlo Cosimo QuattrocchiBruno Beomonte Zobel
Aug 7, 2013·Nature Reviews. Genetics·Miles ParkesMatthew A Brown
Aug 24, 2013·The New England Journal of Medicine·Brian G FeaganUNKNOWN GEMINI 1 Study Group
Aug 24, 2013·The New England Journal of Medicine·William J SandbornUNKNOWN GEMINI 2 Study Group
Aug 27, 2014·The Cochrane Database of Systematic Reviews·Vishal PatelNilesh Chande
Jan 7, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andres J YarurMaria T Abreu
Mar 1, 2015·Gastroenterology·Niels Vande CasteeleSéverine Vermeire
Jul 16, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sedat Alpaslan TuncelHakan Gençhellaç
Nov 4, 2016·The American Journal of Gastroenterology·Stephan R TarganPaul Klekotka

❮ Previous
Next ❯

Citations

May 4, 2021·Frontiers in Immunology·Bing YuBang-Li Hu
Jun 9, 2021·Best Practice & Research. Clinical Rheumatology·Beverly Cheok Kuan Ng, Deepak Rohit Jadon
Oct 9, 2021·Expert Review of Clinical Immunology·Ennio LubranoFabio Massimo Perrotta

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

SpACE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Review of Clinical Pharmacology
Lieven PouillonLaurent Peyrin-Biroulet
The Journal of Rheumatology. Supplement
Paolo GionchettiFernando Rizzello
Nature Reviews. Gastroenterology & Hepatology
Paolo Gionchetti, Fernando Rizzello
© 2021 Meta ULC. All rights reserved