Ibogaine Acute Administration in Rats Promotes Wakefulness, Long-Lasting REM Sleep Suppression, and a Distinctive Motor Profile

Frontiers in Pharmacology
Joaquín GonzálezPablo Torterolo

Abstract

Ibogaine is a potent psychedelic alkaloid that has been the focus of intense research because of its intriguing anti-addictive properties. According to anecdotic reports, ibogaine has been originally classified as an oneirogenic psychedelic; i.e., induces a dream-like cognitive activity while awake. However, the effects of ibogaine administration on wakefulness (W) and sleep have not been thoroughly assessed. The main aim of our study was to characterize the acute effects of ibogaine administration on W and sleep. For this purpose, polysomnographic recordings on chronically prepared rats were performed in the light phase during 6 h. Animals were treated with ibogaine (20 and 40 mg/kg) or vehicle, immediately before the beginning of the recordings. Furthermore, in order to evaluate associated motor behaviors during the W period, a different group of animals was tested for 2 h after ibogaine treatment on an open field with video-tracking software. Compared to control, animals treated with ibogaine showed an increase in time spent in W. This effect was accompanied by a decrease in slow wave sleep (SWS) and rapid-eye movements (REM) sleep time. REM sleep latency was significantly increased in animals treated with the higher ibogain...Continue Reading

References

Jun 1, 1975·European Journal of Pharmacology·T Yamamoto, S Ueki
Apr 3, 1991·European Journal of Pharmacology·S D GlickJ N Carlson
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·M T BardoB A Mattingly
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·M A GeyerV L Masten
Jul 1, 1988·Neuroscience and Behavioral Physiology·T N Oniani, G R Akhvlediani
Sep 1, 1981·Revue d'électroencéphalographie et de neurophysiologie clinique·L Da Costa-RochetteR Naquet
Jan 1, 1980·Revue d'électroencéphalographie et de neurophysiologie clinique·L Da CostaR Naquet
May 1, 1995·Pharmacology, Biochemistry, and Behavior·R P KesnerK Amann
Sep 14, 1993·European Journal of Pharmacology·S L Cappendijk, M R Dzoljic
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·A H RezvaniY W Lee
Jul 1, 1999·Brain Research Bulletin·G B WellsJ C Tanaka
Oct 3, 1999·The American Journal on Addictions·K R AlperJ Bastiaans
Nov 21, 2000·Annals of the New York Academy of Sciences·D C MashM Mayor
Nov 14, 2001·The Alkaloids. Chemistry and Biology·M H BaumannD C Mash
Mar 14, 1957·Annals of the New York Academy of Sciences·J A SCHNEIDER, E B SIGG
Aug 26, 2004·The International Journal of Neuropsychopharmacology·Jaime M Monti, Héctor Jantos
Dec 15, 2010·Journal of Psychopharmacology·Adam L HalberstadtMark A Geyer
Apr 26, 2011·Frontiers in Neurology·Pablo TorteroloJaime M Monti
Feb 9, 2013·Sleep Medicine Reviews·Laura PalaginiDieter Riemann
Feb 15, 2013·The European Journal of Neuroscience·Santiago CastroPablo Torterolo
Mar 13, 2013·Sleep Medicine Reviews·Jaime M MontiPatricia Lagos
Sep 6, 2013·Behavioural Brain Research·Robert HaberzettlMeredith A Fox
Aug 5, 2014·Journal of Pharmacological and Toxicological Methods·Robert HaberzettlBettina Bert
Sep 27, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jaime M MontiPablo Torterolo
Oct 2, 2014·Journal of Psychopharmacology·Eduardo Ekman SchenbergDartiu Xavier da Silveira
Jan 6, 2015·Behavioural Brain Research·Matías CavelliPablo Torterolo
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Feb 15, 2017·Progress in the Chemistry of Organic Natural Products·Catherine Lavaud, Georges Massiot
May 26, 2017·The American Journal of Drug and Alcohol Abuse·Thomas Kingsley Brown, Kenneth Alper
Sep 19, 2017·The European Journal of Neuroscience·Matías CavelliPablo Torterolo

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Methods Mentioned

BETA
column chromatography

Software Mentioned

Ethovision XT
Spike

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