Ibrutinib in Gynecological Malignancies and Breast Cancer: A Systematic Review.

International Journal of Molecular Sciences
Julian Matthias MetzlerPatrick Imesch

Abstract

Ibrutinib is an orally available, small-molecule tyrosine kinase inhibitor. Its main purpose is to inhibit Bruton's tyrosine kinase (BTK), an enzyme that is crucial in B cell development. It is FDA approved for the treatment of certain hematological malignancies. Several promising off-target drug effects have led to multiple, mostly preclinical investigations regarding its use in solid tumors. Unfortunately, data on its effectiveness in gynecological malignancies are limited, and (systematic) reviews are missing. The objective of this review was to summarize the existing literature and to analyze the evidence of ibrutinib as a treatment option in gynecological malignancies, including breast cancer. Studies were identified in MEDLINE and EMBASE using a defined search strategy, and preclinical or clinical research projects investigating ibrutinib in connection with these malignancies were considered eligible for inclusion. Our findings showed that preclinical studies generally confirm ibrutinib's efficacy in cell lines and animal models of ovarian, breast, and endometrial cancer. Ibrutinib exerts multiple antineoplastic effects, such as on-target BTK inhibition, off-target kinase inhibition, and immunomodulation by interference w...Continue Reading

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Sep 29, 2020·Frontiers in Cell and Developmental Biology·Xing-Duo DongZhe-Sheng Chen
Jan 8, 2021·Cancer Metastasis Reviews·Kathryn ColeJames E Talmadge
May 4, 2021·Frontiers in Cell and Developmental Biology·Fatih M Uckun, Taracad Venkatachalam

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Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT02403271
NCT03379428
NCT03525925

Software Mentioned

EMBASE
Emtree
MEDLINE

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