Ibrutinib in primary central nervous system diffuse large B-cell lymphoma.

CNS Oncology
Justin T Low, Katherine B Peters

Abstract

The standard regimen for the treatment of newly diagnosed primary CNS lymphoma (PCNSL) remains regimens that contain high-dose methotrexate (MTX). While these regimens can provide control for some patients, there is a dearth of options for the treatment of patients with PCNSL who cannot tolerate MTX-containing regimens, or whose cancers are refractory to MTX. In this article, we review a promising new option; ibrutinib, a Bruton tyrosine kinase inhibitor, for patients with relapsed and refractory PCNSL.

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Citations

May 8, 2021·Biomarker Research·Yan YuanTong Chen
Oct 21, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·A Moreno-EstébanezL M González

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Methods Mentioned

BETA
biopsies
xenograft

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