Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis

PloS One
Daniel CaldeiraFausto J Pinto

Abstract

Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction. We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials.gov. The data were pooled using random-effects meta-analyses using the risk ratio (RR) with the 95% confidence interval (95%CI). The confidence on the pooled estimates was ascertained through the grading of recommendations assessment, development, and evaluation (GRADE) approach. There were 8 eligible RCTs (2580 patients), all reporting safety data of interest. Ibrutinib was associated with a significant increase in the risk of hypertension with a RR of 2.82 (95%CI 1.52-5.23) with moderate quality evidence. Ibrutinib increased significantly the risk of atrial fibrillation with a RR of 4.69 (95...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Aug 5, 2005·Journal of Biopharmaceutical Statistics·Kurex Sidik, Jeffrey N Jonkman
Dec 1, 2005·Qualitative Health Research·Leslie A WaltersUNKNOWN Hedges Team
May 11, 2006·BMC Medical Research Methodology·Li ZhangMargaret Sampson
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt
May 2, 2013·The Cochrane Database of Systematic Reviews·Feng J HeGraham A Macgregor
Mar 25, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Daniel CaldeiraJoaquim J Ferreira
Jun 3, 2014·The New England Journal of Medicine·John C ByrdUNKNOWN RESONATE Investigators
Mar 17, 2015·Journal of the American College of Cardiology·Gregory Y H LipTorben Bjerregaard Larsen
May 27, 2015·Pharmacoepidemiology and Drug Safety·Daniel CaldeiraJoaquim J Ferreira
Jun 21, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Daniel CaldeiraJoão Costa
Dec 8, 2015·The New England Journal of Medicine·Jan A BurgerUNKNOWN RESONATE-2 Investigators
Jul 14, 2016·BMJ Open·Joanna IntHoutJelle J Goeman
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld
Nov 26, 2016·Leukemia & Lymphoma·Tait D ShanafeltNeil E Kay
Jan 7, 2017·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Jul 9, 2017·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Daniel CaldeiraFausto José Pinto
Aug 9, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Daniel CaldeiraJoão Costa
Apr 3, 2018·The Lancet Oncology·Lucas Moreno
Jun 2, 2018·The New England Journal of Medicine·Meletios A DimopoulosUNKNOWN iNNOVATE Study Group and the European Consortium for Waldenström’s Macroglobulinemia
Aug 22, 2018·Research Synthesis Methods·Areti Angeliki VeronikiGeorgia Salanti
Dec 7, 2018·The New England Journal of Medicine·Jennifer A WoyachJohn C Byrd

❮ Previous
Next ❯

Citations

Jul 19, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Florentina Porsch, Christoph J Binder
Apr 3, 2020·American Society of Clinical Oncology Educational Book·Farrukh T AwanJennifer A Woyach
Jul 8, 2020·Expert Review of Anticancer Therapy·Maria GavriatopoulouMeletios Athanasios Dimopoulos
Dec 4, 2019·JAMA Network Open·Lindsey E RoekerAnthony Mato
Sep 22, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Olivia G FaheyElizabeth N Dow-Hillgartner
Feb 23, 2020·Hypertension·Francisco J RiosRhian M Touyz
Sep 16, 2020·Circulation·James E TisdaleUNKNOWN American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology and Council on Cardiovascul
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Apr 2, 2020·Cold Spring Harbor Perspectives in Medicine·Nicholas ChiorazziKanti R Rai
Feb 13, 2021·Cells·Shelby D MaElena V Galkina
Dec 17, 2020·Life·Valentina GiudiceCarmine Selleri
Feb 23, 2021·Therapeutic Advances in Hematology·Ioannis Ntanasis-StathopoulosMeletios A Dimopoulos
Aug 31, 2020·Hematology/oncology Clinics of North America·David A Bond, Kami J Maddocks
May 29, 2021·Journal of the American College of Cardiology·Vijay U RaoDaniel Lenihan
Jun 1, 2021·Frontiers in Oncology·Hussein A Abbas, William G Wierda
Jun 18, 2021·Expert Opinion on Drug Safety·Magdalini MigkouMeletios Athanasios Dimopoulos
Jul 27, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C ByrdWojciech Jurczak
Aug 4, 2021·Current Oncology Reports·Maude SestierDarryl Leong
Aug 13, 2021·Bone Marrow Transplantation·Akihiro Ohmoto, Shigeo Fuji
Aug 28, 2021·International Journal of Molecular Sciences·Anastasia V PoznyakAlexander N Orekhov
Sep 1, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Husam Abdel-QadirPaaladinesh Thavendiranathan
Oct 12, 2021·Cancer Biology & Therapy·Sara M ZimmermanWilliam D Figg

❮ Previous
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Software Mentioned

OpenMEE
OpenMetaAnalyst
R
Cochrane
RevMan
HELIOS
iNNOVATE

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