Ibrutinib-induced cardiomyopathy

Journal of Community Hospital Internal Medicine Perspectives
Htay Htay KyiSamer Al Hadidi

Abstract

The use of ibrutinib for the treatment of chronic lymphocytic leukemia (CLL) and other hematologic malignancies is blooming. Atrial fibrillation is a known side effect of ibrutinib but cardiomyopathy was not reported previously. We present an 88-year-old man with CLL who was admitted to the hospital with new-onset atrial fibrillation and symptomatic systolic congestive heart failure one month after ibrutinib initiation. Although ibrutinib was discontinued, the patient continues to have a low ejection fraction four months after discontinuation. Ischemic heart disease was ruled out with normal cardiac catheterization. This case highlights a possible new side effect of ibrutinib that needs to be monitored while patients receive this medication.

References

Aug 15, 2009·The American Journal of Pathology·Lynette PretoriusJulie R McMullen
Apr 9, 2015·The New England Journal of Medicine·Steven P TreonRanjana H Advani
Dec 8, 2015·The New England Journal of Medicine·Jan A BurgerUNKNOWN RESONATE-2 Investigators
Oct 22, 2016·Journal of Orthopaedic Trauma·Douglas S WeinbergRaymond W Liu

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Citations

May 31, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sedanur K GülsaranAhmet M Demir
Aug 4, 2021·Current Oncology Reports·Maude SestierDarryl Leong

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Methods Mentioned

BETA
X-ray

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