Ibrutinib-Induced Neutrophilic Dermatosis

The American Journal of Dermatopathology
Layal El HalabiDavid Ghez

Abstract

We report the case of a 64-year-old woman treated with ibrutinib for a chronic lymphocytic leukemia with 17p deletion, who developed several erythematous, painful, and papulo-nodular skin lesions in the limbs, neck, and face. The skin biopsy was consistent with the diagnosis of neutrophilic dermatosis. Rechallenge with ibrutinib at full dose was followed by the recurrence of the same skin lesions, strongly suggesting a direct relationship.

References

Dec 8, 1998·Journal of the American Academy of Dermatology·A S GiasuddinN Y El-Barnawi
Apr 6, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Nicolas KlugerDidier Bessis
Jun 27, 2012·Cancer Immunology, Immunotherapy : CII·Katarina LuptakovaDavid Avigan
Apr 3, 2013·International Journal of Oncology·Shahzad RazaCarl Freter
Jan 19, 2016·Immunity·Stephanie VolmeringAlexander Zarbock

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Citations

Mar 7, 2019·The American Journal of Dermatopathology·Biondo GiovanniCesare Massone
Aug 14, 2020·Dermatologic Therapy·Alessandro PileriBianca Maria Piraccini
Jul 3, 2020·American Journal of Clinical Dermatology·Vincent SibaudLoic Ysebaert
Oct 29, 2020·Dermatologic Therapy·Jason J YangDaniel Q Bach
Feb 14, 2021·Dermatologic Therapy·Lucía Quintana-CastanedoPedro Herranz-Pinto
May 6, 2021·International Journal of Dermatology·Lauren J FriedMiriam K Pomeranz
Oct 9, 2021·Journal of Cutaneous Pathology·Riyad N H SeervaiJonathan L Curry
Nov 3, 2021·Journal of Cutaneous Pathology·Maria Suzanne BloomquistAbdul Hafeez Diwan

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