Abstract
Unlike normal B-cells, and similar to fat cells, chronic lymphocytic leukemia (CLL) cells aberrantly express lipoprotein lipase (LPL), which contributes to free fatty acids (FFAs) metabolism. Here we show that, in CLL cells, the B-cell receptor (BCR) inhibitor ibrutinib reduced LPL mRNA and protein levels and inhibited FFA metabolism in vitro. Likewise, in CLL cells from ibrutinib-treated patients, FFA metabolism was reduced and eventually stopped. Because ibrutinib disrupts CLL cells' ability to use FFAs for energy production, and because various BCR-dependent cellular functions rely on a continuous supply of chemical energy, ibrutinib interrupts several pathways imperative for cellular function in CLL cells.
References
Dec 26, 2001·The Journal of Experimental Medicine·U KleinR Dalla-Favera
Dec 26, 2001·The Journal of Experimental Medicine·A RosenwaldL M Staudt
Dec 17, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·James R MeadDipak P Ramji
Apr 29, 2005·Leukemia·D HeintelU Jäger
Feb 8, 2006·Annals of the New York Academy of Sciences·Nicholas ChiorazziEmilia Albesiano
Dec 7, 2007·Cancer Research·Alessandra FerrajoliZeev Estrov
Dec 15, 2007·Leukemia·C P PallaschC-M Wendtner
Aug 28, 2009·Leukemia Research·Mahmoud MansouriRichard Rosenquist
Oct 12, 2010·PPAR Research·Maryam RakhshandehrooSander Kersten
Jul 26, 2012·Leukemia·P MorenoP Oppezzo
Oct 10, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ranjana H AdvaniNathan H Fowler
Mar 13, 2013·Leukemia Research·Edit PorpaczyKatrina Vanura
Apr 26, 2013·Leukemia & Lymphoma·Cecilia AbreuPablo Oppezzo
Jun 21, 2013·The New England Journal of Medicine·John C ByrdSusan O'Brien
Nov 26, 2013·Leukemia·S ChengY L Wang
Mar 25, 2014·Blood·Sarah E M HermanAdrian Wiestner
Oct 9, 2014·Oncotarget·Lyubov ZaitsevaStuart A Rushworth
Mar 4, 2015·Molecular Cancer Research : MCR·Uri RozovskiZeev Estrov
Apr 4, 2015·Blood·Martin F M de RooijMarcel Spaargaren
Dec 8, 2015·The New England Journal of Medicine·Jan A BurgerUNKNOWN RESONATE-2 Investigators
Dec 9, 2015·Leukemia & Lymphoma·Uri RozovskiZeev Estrov
Oct 1, 2016·Expert Opinion on Drug Metabolism & Toxicology·Prithviraj BoseMichael J Keating
Citations
Aug 25, 2020·Annals of Hematology·Wei LiuGuilin Tang
Aug 1, 2019·Scientific Reports·Bahram Sharif-AskariRaquel Aloyz
Aug 29, 2019·International Journal of Molecular Sciences·Anna C Beielstein, Christian P Pallasch
Oct 16, 2018·Frontiers in Oncology·Gabriela Galicia-Vázquez, Raquel Aloyz
Sep 21, 2018·Journal of Neuroinflammation·Hye Yeon NamHyang-Sook Hoe
Dec 1, 2020·Frontiers in Oncology·Martin BöttcherDimitrios Mougiakakos
Jun 28, 2021·BMC Cancer·Zhuojun LiuJian Yu
Oct 16, 2021·Hematological Oncology·Haoran WangKeshu Zhou