iBTA-induced bovine Biosheet for repair of abdominal wall defects in a beagle model: proof of concept

Hernia : the Journal of Hernias and Abdominal Wall Surgery
Yasuhide NakayamaT Nishimura

Abstract

We evaluated the usefulness of xeno-Biosheets, an in-body tissue architecture-induced bovine collagenous sheet, as repair materials for abdominal wall defects in a beagle model. Biosheets were prepared by embedding cylindrical molds into subcutaneous pouches of three Holstein cows for 2-3 months and stored in 70% ethanol. The Biosheets were 0.5 mm thick, cut into 2 cm × 2 cm, and implanted to replace defects of the same size in the abdominal wall of nine beagles. The abdominal wall and Biosheets were harvested and subjected to histological evaluation at 1, 3, and 5 months after implantation (n = 3 each). The Biosheet and bovine pericardiac patch (control) were not stressed during the suture operation and did not split, and patches were easily implanted on defective wounds. After implantation, the patch did not fall off and was not perforated, and healing was observed nacroscopically in all cases. During the first month of implantation, accumulation of inflammatory cells was observed along with decomposition around the Biosheet. Decomposition was almost complete after 3 months, and the Biosheet was replaced by autologous collagenous connective tissue without rejection. After 5 months, the abdominal wall muscle elongated from the...Continue Reading

References

Sep 23, 2008·The Journal of Thoracic and Cardiovascular Surgery·Charles A YankahRoland Hetzer
Oct 1, 2011·The Annals of Thoracic Surgery·Pascal M DohmenWolfgang Konertz
Mar 29, 2014·Journal of Tissue Engineering and Regenerative Medicine·Naoaki TakiyamaYasuhide Nakayama
Dec 21, 2016·Journal of the American College of Surgeons·Patrick B GarveyCharles E Butler
Dec 11, 2017·Journal of Pediatric Surgery·Hiroomi OkuyamaYasuhide Nakayama
Dec 16, 2017·Journal of Pediatric Surgery·Keisuke SuzukiYasuhide Nakayama
Jan 30, 2018·Journal of Biomaterials Science. Polymer Edition·Zhu-Le WangHui-Qi Xie
Mar 9, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yoshiaki TakewaYasuhide Nakayama
Mar 24, 2018·The Journal of Thoracic and Cardiovascular Surgery·Shigeyuki OzakiNagaki Kiyohara
Apr 1, 2018·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takeshi TerazawaYasuhide Nakayama
Apr 18, 2018·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Daizo IshiiYasuhide Nakayama

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