PMID: 6985377Jun 1, 1982Paper

Ibuprofen-induced meningitis in mixed connective tissue disease

Clinical Rheumatology
M Hoffman, R G Gray

Abstract

A young Black woman with mixed connective tissue disease (MCTD) developed an aseptic meningitis after receiving ibuprofen. The meningeal reaction, reported infrequently in systemic lupus erythematosus (SLE) and only once previously in MCTD, was characterized by a predominantly polymorphonuclear cerebrospinal fluid (CSF) pleocytosis and depression of CSF glucose. Reversible renal insufficiency also occurred. Features suggestive of a hypersensitivity reaction included pruritus, conjunctivitis, facial oedema, desquamation of the palms and soles, and subsequent near total alopecia. Meningeal signs responded rapidly to systemic corticosteroid therapy. Patients with MCTD as well as those with SLE may be at peculiar risk of developing this uncommon reaction to ibuprofen.

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Citations

Feb 27, 2004·Rheumatology International·Edit BodolayZoltán Szekanecz
Dec 2, 2009·Inflammopharmacology·K D Rainsford
Jan 1, 1989·Clinical Neurology and Neurosurgery·Y YasudaM Kameyama
May 10, 2011·Revue neurologique·N KhammassiO Cherif
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Paul Kim, Jennifer M Grossman
Jul 1, 1993·Journal of Child Neurology·W D GrafD D Sherry
Jan 25, 2018·Fundamental & Clinical Pharmacology·Melissa Yelehe-OkoumaPierre Gillet
Nov 25, 2003·Scandinavian Journal of Rheumatology·J OkadaH Kondo
Mar 30, 2005·Expert Opinion on Drug Safety·Susan Hopkins, Stephen Jolles
Jan 1, 1987·Acta Medica Scandinavica·S JensenH Ersgaard

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