PMID: 2106806Mar 1, 1990Paper

Ibuprofen pretreatment inhibits prostacyclin release during abdominal exploration in aortic surgery

Anesthesiology
J C HudsonW D Watkins

Abstract

Mesenteric traction during aortic surgery produces facial flushing, reduced mean arterial pressure (MAP), and systemic vascular resistance (SVR) with increased heart rate (HR) and cardiac index (CI). Elevated 6-keto-prostaglandin-F1 alpha (6-keto-PGF1 alpha) suggests prostacyclin is the mediator. To test this hypothesis, the cyclooxygenase inhibitor, ibuprofen (n = 14), or placebo (n = 13) was administered to patients electively scheduled for aortic reconstruction. The hemodynamic measurements and plasma concentrations of prostanoids between groups were compared immediately before (0), and 5, 10, 15, 30, and 45 min following mesenteric traction. Following mesenteric traction significant differences (P less than 0.05) were observed between the ibuprofen pretreatment and placebo group over time in SVR, MAP, HR, CI, 6-keto-PGF1 alpha, and thromboxane B2 (TXB2). Significant differences between groups at individual times were found in SVR, HR, CI, 6-keto-PGF1 alpha, and TXB2. In the placebo group flushing was accompanied by reduced SVR and MAP and increased HR and CI. The greatest effect was seen at 10 min and resolved over 30 min. Plasma concentration of 6-keto-PGF1 alpha increased from 159 +/- 103 (mean +/- SEM) pg/ml to a peak va...Continue Reading

Associated Clinical Trials

Citations

Oct 13, 2006·International Anesthesiology Clinics·Andre M De Wolf
Oct 17, 1998·Acta Anaesthesiologica Scandinavica·A BrinkmannM Georgieff
Jan 6, 2005·International Anesthesiology Clinics·Michael F WozniakGuido Musch
May 1, 1997·Immunopharmacology and Immunotoxicology·M WeissH Lemoine
Apr 5, 2016·Journal of Clinical Anesthesia·Hidemasa TakahashiTakeo Suzuki
Mar 1, 1993·Disease-a-month : DM·E BenjaminT J Iberti
Aug 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·T W LatsonR J Valentine
Apr 4, 2006·European Journal of Pharmacology·Michael BucherJonny Hobbhahn
Nov 30, 2016·A & a Case Reports·Alfredo Haack CoutoRogério Luiz da Rocha Videira
Oct 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·M E Comunale, S A Neilly
Jul 25, 2017·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·R AmbrusM P Achiam

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