PMID: 3516203Mar 1, 1986Paper

Ibuprofen prevents IUCD-induced increases in menstrual blood loss

British Journal of Obstetrics and Gynaecology
L Mäkäräinen, O Ylikorkala

Abstract

To study the effects of a copper-releasing intrauterine contraceptive device (IUCD) and a prostaglandin (PG) synthesis inhibitor, ibuprofen, on menstrual blood loss, 28 healthy women received either a Fincoid 350 or a ML Cu375 device and were then treated in a double-blind randomized manner with ibuprofen (1200 mg daily) or a placebo during their next three menstruations. The preinsertion menstrual blood loss (2 cycles) was normal for healthy women (median 38 ml) with no difference between women who subsequently received either Fincoid 350 or ML Cu375 and ibuprofen or placebo treatment. The median increase in menstrual blood loss after the insertion of an IUCD was 74% (P less than 0.01) in women receiving placebo treatment, and this rise was not dependent on the type of IUCD. Ibuprofen treatment prevented the increase in blood loss following IUCD insertion, but it failed to shorten the duration of menstruation. Four women reported side-effects (tiredness, irritability, sweating, dyspepsia) during ibuprofen treatment, and two women did so during placebo treatment. It is concluded that IUCDs with a large copper surface also increase menstrual blood loss, but that this increase can be prevented with ibuprofen treatment.

References

Feb 21, 1976·Lancet·J GuillebaudA Matthews
Jan 1, 1978·British Journal of Obstetrics and Gynaecology·J GuillebaudA C Turnbull
Sep 1, 1975·Contraception·P LiedholmL Sölvell
Jan 1, 1975·Acta Obstetricia Et Gynecologica Scandinavica·B LarssonG Rybo
May 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P J HaynesA C Turnbull
Mar 14, 1981·Lancet·G RyboK G Nygren
Jun 1, 1983·British Journal of Obstetrics and Gynaecology·L Mäkäräinen, O Ylikorkala
Jan 1, 1964·Scandinavian Journal of Clinical and Laboratory Investigation·L HALLBERG, L NILSSON

Citations

Jun 1, 1995·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·N P Noerpramana
Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·I S Fraser
Nov 25, 2015·Obstetrics and Gynecology Clinics of North America·EmmaKate Friedlander, Bliss Kaneshiro
Nov 1, 2006·American Journal of Obstetrics and Gynecology·D HubacherHoracio Croxatto
Jun 16, 1990·BMJ : British Medical Journal·A L Magos
Jun 18, 2010·The Cochrane Database of Systematic Reviews·G Justus HofmeyrTheresa A Lawrie
Oct 21, 2006·The Cochrane Database of Systematic Reviews·D A GrimesK F Schulz
Aug 6, 1995·Quality in Health Care : QHC·A CoulterT A Sheldon

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.