PMID: 15248627Jul 14, 2004Paper

Ibuprofen vs. acetaminophen vs. ibuprofen and acetaminophen after arthroscopically assisted anterior cruciate ligament reconstruction

European Journal of Anaesthesiology
V DahlJ C Raeder

Abstract

The analgesic potency of non-steroidal anti-inflammatory drugs and acetaminophen are still being debated. We have assessed the relative analgesic effect of ibuprofen, acetaminophen or the combination of both after orthopaedic surgery. Sixty-one ASA I patients, scheduled for an elective anterior cruciate ligament reconstruction under general anaesthesia were randomized, in a double blind fashion, into one of three groups. The ibuprofen group (n = 17) received ibuprofen 800 mg orally 1 h before operation and again at 6 and 12 h after the initial dose. The acetaminophen group (n = 20) received of acetaminophen 1 g orally at the same time intervals. The combination group (n = 24) received both ibuprofen 800 mg and acetaminophen 1 g. Surgery was performed under general anaesthesia with propofol and fentanyl for induction and maintenance with propofol and nitrous oxide in oxygen. The patients were monitored for 24 h thereafter, and the following variables were assessed: pain by visual analogue and verbal scales, need for rescue intravenous opioid analgesia (i.e. ketobemidone) and adverse events. The ibuprofen group and the combination group experienced significantly less pain during the first 6 h after surgery than the acetaminophen ...Continue Reading

References

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Citations

Jul 5, 2011·Paediatric Anaesthesia·Jacqueline Hannam, Brian J Anderson
Jul 16, 2008·Acta Orthopaedica·Sigbøjrn DimmenJan Erik Madsen
Mar 26, 2009·Clinical Orthopaedics and Related Research·Sigbjorn DimmenJan Erik Madsen
Feb 24, 2006·European Journal of Pain : EJP·Luis RomundstadHarald Breivik
Apr 24, 2019·The Cochrane Database of Systematic Reviews·Daniel Molano FrancoIngrid Arevalo-Rodriguez
Aug 23, 2017·British Journal of Sports Medicine·Brian HainlineLars Engebretsen
Feb 4, 2011·Acta Orthopaedica. Supplementum·Sigbjørn Dimmen

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