IBZM tool: a fully automated expert system for the evaluation of IBZM SPECT studies.

European Journal of Nuclear Medicine and Molecular Imaging
Ralph BuchertMalte Clausen

Abstract

Visual reading of [(123)I]IBZM SPECT scans depends on the experience of the interpreter. Therefore, semi-quantification of striatal IBZM uptake is commonly considered mandatory. However, semi-quantification is time consuming and prone to error, particularly if the volumes of interest (VOIs) are positioned manually. Therefore, the present paper proposes a new software tool ("IBZM tool") for fully automated and standardised processing, evaluation and documentation of [(123)I]IBZM SPECT scans. The IBZM tool is an easy-to-use SPM toolbox. It includes automated procedures for realignment and summation of multiple frames (motion correction), stereotactic normalisation, scaling, VOI analysis of striatum-to-reference ratio R, classification of R and standardised display. In order to evaluate the tool, which was developed at the University of Hamburg, the tool was transferred to the University of Hannover. There it was applied to 27 well-documented subjects: eight patients with multi-system atrophy (MSA), 12 patients with Parkinson's disease (PD) and seven controls. The IBZM tool was compared with manual VOI analysis. The sensitivity and specificity of the IBZM tool for the differentiation of the MSA subjects from the controls were 100%...Continue Reading

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Citations

Dec 3, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Kosmas BadiavasNikolaos Karatzas
Jul 10, 2013·Journal of Neurology·Daniel JussenJohann Sebastian Braun
Sep 3, 2011·Annals of Nuclear Medicine·I-Cheng ChangChih-Hao K Kao
Oct 20, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Koen Van LaereJacques Darcourt
Feb 6, 2010·Revista española de medicina nuclear·C Paniagua CorreaC Pey Illera
Sep 12, 2014·Nuklearmedizin. Nuclear Medicine·D KupitzR Buchert
Dec 12, 2012·Journal of Hepatology·Anita B TrycKarin Weissenborn
Apr 25, 2012·Journal of Biomedicine & Biotechnology·Ling WangHong Zhang
Oct 1, 2014·PloS One·Catharina LangeRalph Buchert
Mar 16, 2018·PloS One·Cheng-Han WuJyh-Cheng Chen
Dec 1, 2007·Nuclear Medicine Communications·Ralph BuchertVictor F Mautner
Mar 23, 2010·Clinical Nuclear Medicine·Paloma PifarréJoan Castell-Conesa
Jun 16, 2010·The American Journal of Drug and Alcohol Abuse·Aviv Malkiel Weinstein
Dec 26, 2015·Nuclear Medicine Communications·Ralph BuchertJerome Declerck

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