ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins

Biochemical and Biophysical Research Communications
P D SmithM R Crompton

Abstract

We have isolated a cDNA from human foetal brain cDNA library which encodes a putative transmembrane protein bearing an intracellular protein tyrosine phosphatase (PTPase) like domain. The PTPase like domain contains an alanine to aspartate amino acid change relative to other PTPases in the catalytic core domain. This amino acid change is found in only three other known proteins, islet cell autoantigens; human, murine and rat IA-2, murine IA-2b and its rat orthologue phogrin, which have a similar overall structure to ICAAR, and the recently identified X-linked myotubular myopathy (MTM1) gene. ICAAR, IA-2 and IA-2b clearly represent a new family of PTP-like proteins for which catalytic activity has yet to be demonstrated. An abundant ICAAR mRNA is detectable in the brain and pancreas but not in the other normal human tissues surveyed. We have localised ICAAR to human chromosome 7q36.

Citations

Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Asako DoiKishio Nanjo
Apr 25, 2008·Pharmacology & Therapeutics·Katsuya DezakiToshihiko Yada
Oct 30, 2013·Human Vaccines & Immunotherapeutics·Anna K E RydénMatthias G Von Herrath
Dec 9, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E H LeiterA L Notkins
Apr 30, 1998·Current Opinion in Cell Biology·D Van Vactor
Oct 3, 1998·Trends in Biochemical Sciences·M J Wishart, J E Dixon

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