ICAM-1 and iNOS expression increased in the skin of mice after vaccination with gamma-irradiated cercariae of Schistosoma mansoni

Experimental Parasitology
K RamaswamyB Salafsky

Abstract

Host responses to migrating schistosomula of Schistosoma mansoni were compared in the skin of naive, multiply infected, or vaccinated (with gamma-irradiated cercariae) mice during the first 72 hr after cercarial penetration. Cellular response to the migrating parasite was minimal in the skin of naive mice for up to 72 hr after infection. In sharp contrast, the multiply infected or vaccinated animals exhibited a marked inflammatory response in the skin as early as 8 hr after cutaneous penetration of the challenge cercariae. This early inflammatory response in the skin of sensitized animals was characterized by a significant increase in the number of infiltrating cells, predominantly mononuclear cells and neutrophils. Increased exudation of serum proteins was also present in the skin of sensitized animals in areas of cercarial challenge. A time course of analyses revealed that mononuclear cell numbers increased significantly in the skin of vaccinated animals as early as 60 min after a challenge infection and continued to be present at a significantly higher level up to 72 hr after challenge. Peak neutrophil responses occurred in the skin at 24 hr (in multiply infected animals) and at 48 hr (in vaccinated animals) after a challeng...Continue Reading

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Citations

Jun 7, 2002·The Journal of Biological Chemistry·Kakuturu V N RaoK Ramaswamy
Jul 17, 2008·PLoS Neglected Tropical Diseases·Elizabeth HansellJames H McKerrow
Apr 5, 2013·PLoS Neglected Tropical Diseases·Christine E FerragineStephen J Davies
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Related Concepts

Extravasation of Diagnostic and Therapeutic Materials
X-Rays, Nuclear
Cellular Immune Response
Immunocytochemistry
Iodine Radioisotopes
Isotope Labeling, Stable
Lung
Neutrophil Band Cells
Schistosoma mansoni
Schistosomiasis Mansoni

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