ICAM-1 and VCAM-1 expression in accelerated cardiac allograft arteriopathy and myocardial rejection are influenced differently by cyclosporine A and tumour necrosis factor-alpha blockade

The Journal of Pathology
S MolossiM Rabinovitch

Abstract

Expression of the vascular cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) occurs in allograft myocardium and in coronary arteries, promoting adhesion and transendothelial migration of inflammatory cells. We therefore investigated, in cholesterol-fed rabbits 9-10 days following heterotopic cardiac transplantation, whether the reduction of both myocardial rejection and graft arteriopathy with cyclosporine A (CsA) or graft arteriopathy alone with tumour necrosis factor-alpha soluble receptor (TNFsr) was associated with suppression of ICAM-1 and VCAM-1 expression. Host hearts showed negative immunostaining for these adhesion molecules, whereas donor specimens from untreated (control) rabbits showed moderate immunostaining for ICAM-1 and weaker immunostaining for VCAM-1 in the coronary arteries, myocardium (cardiac myocytes), and perivenular regions. The selective reduction of the coronary arteriopathy with TNFsr was associated with somewhat reduced expression of these adhesion molecules in the arteries, whereas CsA also suppressed myocardial rejection and markedly decreased both vascular and myocyte expression of ICAM-1 and VCAM-1.

References

Jan 1, 1993·International Review of Experimental Pathology·C A JacobsD H Lynch
Nov 1, 1993·Clinical Immunology and Immunopathology·M N TengH Schreiber

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Citations

Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heiko MetheJoerg Koglin
Jan 1, 2005·Inflammatory Bowel Diseases·Antonio Soriano-IzquierdoJulián Panés
Dec 1, 1995·Acta Paediatrica Japonica; Overseas Edition·M Rabinovitch
Nov 28, 2007·Annual Review of Pathology·Marlene Rabinovitch
Feb 5, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Sonja SchrepferHermann Reichenspurner
Oct 10, 2001·Clinics in Chest Medicine·M Rabinovitch

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