PMID: 15387368Sep 25, 2004Paper

ICAM-1 supports adhesion of human small-cell lung carcinoma to endothelial cells

Clinical & Experimental Metastasis
Angela H FinzelLaurenz J Wurzinger

Abstract

Adhesion of tumor cells to endothelium via cell-adhesion molecules constitutes a crucial step in metastasis, which is largely responsible for the poor prognosis of small-cell lung carcinoma (SCLC). Patients with SCLC were reported to have elevated levels of intercellular adhesion molecule-1 (ICAM-1). The present study therefore focusses on endothelial ICAM-1 in tumor-cell adhesion. We found that the adherence of SCLC cells (cell lines H24, H69, H82) to cultured vascular endothelium in stasis and flow depends on the expression of ICAM-1. After blocking endothelial ICAM-1 with monoclonal antibodies, adhesion was significantly reduced. These results pinpoint ICAM-1 for the first time as a molecule crucially involved in SCLC cell-endothelial adhesion.

Citations

Dec 6, 2005·Journal of Biomedical Science·Wen-Bin LiuCheng-Chao Shou
Nov 21, 2007·Surgical Oncology Clinics of North America·Dominik RüttingerBernard A Fox
Oct 11, 2008·Fundamental & Clinical Pharmacology·G Y Perret, M Crépin
Nov 12, 2009·International Journal of Cancer. Journal International Du Cancer·Krzysztof KsiazekJanusz Witowski
Mar 1, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G Egri, A Takáts
Jun 28, 2013·Cellular and Molecular Bioengineering·Yue GengMichael R King
Jun 3, 2021·Cancers·Elisenda Alsina-SanchisAndreas Fischer

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