Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A

Endocrinology
Kirsten S EckstrumLori T Raetzman

Abstract

Endocrine-disrupting chemicals are prevalent in the environment and can impair reproductive success by affecting the hypothalamic-pituitary-gonadal axis. The developing pituitary gland is sensitive to exposure to endocrine-disrupting chemicals, such as bisphenol A (BPA), and sex-specific effects can occur. However, effects on the critical window of neonatal pituitary gland development in mice have not been explored. Therefore, this study determined baseline gene expression in male and female pituitaries and consequences of environmental exposure to 17β-estradiol (E2) and BPA on transcription of genes exhibiting sex differences during the neonatal period. Through microarray and quantitative RT-PCR analysis of pituitaries at postnatal day (PND)1, 3 genes were differentially expressed between males and females: Lhb, Fshb, and intracellular adhesion molecule-5 (Icam5). To see whether E2 and BPA exposure regulates these genes, pituitaries were cultured at PND1 with 10(-8) M E2 or 4.4 × 10(-6) M BPA. E2 decreased expression of Lhb, Fshb, and Icam5 mRNA in females but only significantly decreased expression of Icam5 in males. BPA decreased expression of Icam5 similarly to E2, but it did not affect Lhb or Fshb. Importantly, in vivo exp...Continue Reading

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Citations

Oct 25, 2016·Toxicology and Applied Pharmacology·Karen E Weis, Lori T Raetzman
Dec 10, 2016·Nature Reviews. Endocrinology·Paul Le TissierPatrice Mollard
May 15, 2018·Biology of Reproduction·Whitney Edwards, Lori T Raetzman
Feb 13, 2020·Journal of Clinical Medicine·Francesco PallottiDonatella Paoli
Apr 2, 2016·Endocrinology·Paul R Le Tissier, Patrice Mollard
Mar 20, 2020·International Journal of Molecular Sciences·Branka Šošić-JurjevićVerica Milošević
Jul 2, 2020·Environmental Science and Pollution Research International·Joseph A AdeyemiFernando Barbosa

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