PMID: 29997094Jul 13, 2018Paper

Icariin alleviates lipid peroxidation after spinal cord injury in rats

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Xian-Sheng RenXiao-Yu Yang

Abstract

To assess the effects of intragastric administration of icariin on lipid peroxidation after spinal cord injury in rats. Seventy-two healthy adult male SD rats were randomized equally into icariin group, control group and sham-operated group. In the control and icariin groups, spinal cord injury was induced using modified Allen's method, and the rats in the sham-operated group underwent laminotomy without damaging the spinal cord. Immediately after the surgery, the rats in icariin group were subjected to intragastric administration of icariin (100 mg/kg), and those in the control and sham-operated groups received an equal volume of saline in the same manner once a day. At 24 h after the operation, malondialdehyde (MDA) content was detected using thiobarbituric acid method, superoxide dismutase (SOD) activity was measured with xanthine oxidase method, and the water content in the spinal cord was measured using dry-wet weight method. At 48 h after the operation, the ultrastructure of the spinal cord was observed with transmission electron microscopy and scored using Kaptanoglu scoring method. The motor function of the rats was assessed using BBB scoring at 7, 14, 21 and 28 days after the operation. At 24 h after the operation, MDA...Continue Reading

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