Icariin alleviates murine lupus nephritis via inhibiting NF-κB activation pathway and NLRP3 inflammasome

Life Sciences
Bofeng SuLinlin Li

Abstract

Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). Both NF-κB activation and NLRP3 inflammasome activation are implicated in LN pathogenesis, suggesting they are potential targets for LN treatment. Icariin, which is isolated from Chinese medicine Horny Goat Weed (Ying Yang Huo), has been shown to have anti-inflammation activity, and inhibit activations of both NF-κB and NLRP3 inflammasome. In present study, the effects of icariin on LN were evaluated in MRL/lpr mice. We treated MRL/lpr mice with icariin for 8 weeks and then analyzed the renal function and kidney pathology. We monitored the levels of anti-dsDNA antibody and the deposition of immune complex after icariin treatment. We also detected the macrophage infiltration, NF-κB activation, NLRP3 inflammasome activation and inflammatory cytokine TNF-α production in MRL/lpr mice after icariin treatment. We found that MRL/lpr mice treated with icariin displayed significantly attenuated the renal disease. Icariin-treated mice showed significantly reduced serum anti-dsDNA antibody level and immune complex deposition. Icariin inhibited NF-κB activation and TNF-α production in MRL/lpr mice. Icariin inhibited CCL2 production and macro...Continue Reading

Citations

Jul 18, 2019·International Journal of Molecular Sciences·Francesca BonominiRita Rezzani
Feb 16, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chung-Yao WuAnn Chen
May 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zi YangTing Zhao
Apr 19, 2020·International Immunopharmacology·Brice Ayissi OwonaPaul Fewou Moundipa
Jan 10, 2021·International Journal of Molecular Sciences·Young-Su Yi
Feb 17, 2021·Acta Pharmacologica Sinica·Li ChenJian-Ping Zuo
Mar 20, 2021·Journal of Integrative Medicine·Mohamed Ismail NounouDoreen Szollosi
Apr 16, 2021·Frontiers in Pharmacology·Mingming ZhaoYu Zhang
Jul 3, 2021·Antioxidants·Burak Ibrahim AriozSermin Genc
Aug 2, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhe LiLiqi Bi

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