Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

Cell Biochemistry and Biophysics
Xing MengChao Lan

Abstract

Icariin, a plant-derived flavonoid, has multiple beneficial actions on the cardiovascular system. The current study investigated whether icariin postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. In in vivo rat model of myocardial ischemia/reperfusion, we found that postconditioning with icariin significantly reduced myocardial infarct size, serum level of TNF-α and IL-10, TNF-α and IL-10 expression, and apoptosis. Moreover, our results showed that icariin postconditioning exerts cardioprotective effect against myocardial I/R injury through activating PI3K/Akt using PI3K/Akt inhibitor LY294002.

References

Dec 18, 2001·Cardiovascular Research·Nikolaos G FrangogiannisMark L Entman
Jun 1, 2002·Science·Lewis C Cantley
Oct 2, 2002·Journal of the American College of Cardiology·Steven P JonesDavid J Lefer
Jan 30, 2007·Hematology/oncology Clinics of North America·Jakob Vinten-JohansenLynetta J Jobe
Jul 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Sophie TamareilleFabrice Prunier
May 11, 2010·Acta Pharmacologica Sinica·Shuang ZhangShi-jie Yang
Jul 14, 2010·Pharmacology & Therapeutics·Petra KleinbongardRainer Schulz
Jul 21, 2010·The American Journal of Cardiology·Aslan T Turer, Joseph A Hill
Nov 18, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yang ChenZi-yin Shen
Mar 31, 2012·International Journal of Cardiology·Martinus I F J OerlemansJoost P G Sluijter
Jun 26, 2012·The Journal of Surgical Research·Qiao-ling WuJun-ke Wang
Sep 4, 2013·International Journal of Molecular Sciences·Qiufang ZhangXuanbin Wang
Sep 27, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Y WangY L Wang
Nov 19, 2014·Molecular Medicine Reports·Xinhong GuoJianguo Xing

❮ Previous
Next ❯

Citations

Apr 4, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Julius LiobikasVilmante Borutaite
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yao-Hong SongMeng-Ling Wu
Jun 23, 2020·The Journal of Pharmacy and Pharmacology·Jinwu WangLeyi Cai
May 26, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Xiangyu DengHongzhi Hu
Mar 5, 2019·International Journal of Radiation Biology·Byung Kil ParkByung Ho Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Y WangY L Wang
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Zi-Xi GongJun-Mei Xu
© 2022 Meta ULC. All rights reserved