Icariin inhibits the increased inward calcium currents induced by amyloid-beta(25-35) peptide in CA1 pyramidal neurons of neonatal rat hippocampal slice

The American Journal of Chinese Medicine
Li LiXue-Mei Wang

Abstract

Overload of intracellular calcium caused by amyloid-beta peptide has been implicated in the pathogenesis of neuronal damage in Alzheimer's disease. Voltage-gated calcium channels (VGCCs) provide one of the major sources of Ca(2+) entry into cells. Here, we investigated whether icariin had effect on the changes of calcium currents induced by Abeta(25-35) in hippocampal pyramidal neurons. Using whole-cell patch-clamp, we showed that Abeta(25-35) enhanced the inward Ba(2+) and Ca(2+) currents. The currents were partially inhibited by Ni(2+) and completely suppressed by Cd(2+), indicating that Abeta(25-35) disrupts intracellular calcium homeostasis via the modulation of both L- and T-type channels. Furthermore, icariin nearly complete suppressed the abnormal inward calcium currents induced by Abeta(25-35) in a dose-dependant manner. Our findings suggest that the potential neuroprotective effect of icariin on Abeta(25-35)-induced neurotoxicity via the balance intracelluar calcium homeostasis.

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Citations

Nov 6, 2010·Archives of Pharmacal Research·So-Young Park
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Igor KlyubinMichael J Rowan
Sep 4, 2013·International Journal of Molecular Sciences·Qiufang ZhangXuanbin Wang
Jan 20, 2016·International Journal of Molecular Sciences·Zhijie CuiKailin Tang
May 21, 2011·The American Journal of Chinese Medicine·Su-Jin KimSeung-Heon Hong
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Shao-Yang ZhaoKe-Wu Zeng
Nov 13, 2010·Natural Product Reports·Philip WilliamsMelanie-Jayne R Howes
Dec 22, 2016·Chinese Journal of Integrative Medicine·Lin-Lin WangXue-Mei Wang
Apr 4, 2019·Frontiers in Pharmacology·Cristina AngeloniSilvana Hrelia

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