Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells.

British Journal of Pharmacology
Sao-Keng MokMan-Sau Wong

Abstract

Icariin may be the active ingredient in Herba Epimedii, a Chinese herb commonly used for treatment of osteoporosis. The present study aims to delineate the mechanism(s) by which icariin prevents bone loss after ovariectomy (OVX) in vivo and stimulates osteoblastic functions in vitro. Ovariectomized or sham-operated C57BL/6 mice were treated with vehicle, 17beta-oestradiol or icariin for 6 weeks. Total and trabecular bome mineral density (BMD) as well as polar stress-strain index of distal femur were measured by peripheral computed tomography. The mRNA expressions of OPG and RANKL in tibia were studied by RT-PCR. Interactions between the oestrogen receptor (ER) antagonist ICI182,780 and icariin were studied in UMR 106 cells. The functional transactivation of ERalpha and ERbeta as well as ERalpha phosphorylation by icariin were also assessed. Icariin suppressed the loss of bone mass and strength in distal femur and increased the mRNA expression ratio of OPG/RANKL in tibia, following OVX. Icariin increased ER-dependent cell proliferation, alkaline phosphatase (ALP) activity, gene expression of OPG and the OPG/RANKL ratio in UMR 106 cells. Icariin did not activate ERE-luciferase activity in UMR 106 cells, via the ERalpha or the ERb...Continue Reading

References

Jul 25, 1989·Nucleic Acids Research·J A LeesM G Parker
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Sep 21, 2004·Annual Review of Plant Biology·Richard A Dixon
Jun 14, 2005·European Journal of Clinical Investigation·A Gal-MoscoviciM M Popovtzer
Sep 2, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Fang XieMan-Sau Wong
Feb 8, 2006·Clinical Orthopaedics and Related Research·Jean-Yves Reginster, Jean-Pierre Devogelaer
Jun 14, 2006·The British Journal of Nutrition·Wen-Fang Chen, Man-Sau Wong
Dec 13, 2006·Molecular and Cellular Biology·Stavroula KousteniStavros C Manolagas
Jan 20, 2007·Drugs & Aging·Alexandra PapaioannouJonathan D Adachi
Apr 11, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ge ZhangYinyu Shi
Jul 27, 2007·Climacteric : the Journal of the International Menopause Society·M GambaccianiA R Genazzani
Oct 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Wai-Sum LauMan-Sau Wong
Feb 26, 2008·Biochemical and Biophysical Research Communications·Jiyuan ZhaoTeruyuki Nagamune
May 2, 2008·British Journal of Pharmacology·S P H AlexanderJ A Peters
Sep 16, 2008·Biochemical and Biophysical Research Communications·Byung-Hee ChungYoung-Myeong Kim
Mar 10, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H NianL-L Xu

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Citations

Nov 18, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yang ChenZi-yin Shen
Jan 21, 2014·BMC Complementary and Alternative Medicine·Yoshiki MukudaiSatoru Shintani
Jul 24, 2012·Regenerative Medicine·Kevin W-H LoCato T Laurencin
Mar 13, 2014·Chinese Journal of Integrative Medicine·Jian-hua HuangZi-yin Shen
May 9, 2014·Journal of Diabetes Research·Xinyu ShaoBimin Shi
Jan 31, 2014·Journal of Periodontology·Zhenhua PeiLi Mei
Jan 29, 2016·Pharmacology & Therapeutics·Inthrani Raja IndranEu-Leong Yong
Mar 9, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ming-Jaw DonWen-Fei Chiou
Feb 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Min JiaLu-Ping Qin
Mar 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Tao CheChristopher Wai Kei Lam
Jul 11, 2012·Journal of Cellular Physiology·Lei-Guo MingCory J Xian
Feb 18, 2011·Journal of Cellular Biochemistry·Hui-Ping MaKe-Ming Chen
Jul 5, 2013·Phytotherapy Research : PTR·Xin ZhangYuelian Liu
Aug 6, 2015·The American Journal of Chinese Medicine·Xiao-Jia ChenYi-Tao Wang
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Feng LiYong-Jun Wang
Nov 15, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chun-Hay KoPing-Chung Leung
Jun 26, 2014·Pharmaceutical Biology·Emmanuel MukwayaYan Zhang
Jun 15, 2016·Chinese Journal of Integrative Medicine·Wing-Sum SiuPing-Chung Leung
Oct 30, 2016·International Journal of Molecular Sciences·Chenyi YeRongxin He
Jan 29, 2014·The American Journal of Chinese Medicine·Chenrui LiQibing Mei
Apr 9, 2014·The American Journal of Chinese Medicine·Ka-Chun WongMan-Sau Wong
Jan 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuncong ZhangDe Liang
Jul 1, 2017·The American Journal of Chinese Medicine·Yan-Mei ShuiJian-Li Gao
Apr 17, 2015·Journal of Biomaterials Applications·Xiaowei XiePengde Kang

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