Icariin protects against thioacetamide-induced liver fibrosis in rats: Implication of anti-angiogenic and anti-autophagic properties

Pharmacological Reports : PR
Mardi M AlgandabyOsama M Ashour

Abstract

Liver fibrosis is a major health problem. The current study evaluated the potential of icariin (ICA) to guard against thioacetamide (TAA)-induced liver fibrosis in rats. Four groups of male rats were treated as follows: group 1 was the control group, group 2 was given TAA (200mg/kg), group 3 was administered ICA (50mg/kg) and TAA (200mg/kg), and group 4 was given ICA (50mg/kg) alone. Animal treatment was continued for four weeks. Co-administration of ICA guarded against TAA hepatotoxicity as indicated by significant inhibition in the rise of serum ALT and AST activities and albumin concentrations. This was accompanied by inhibition of reduced glutathione depletion, superoxide dismutase exhaustion, and lipid peroxide accumulation. In addition, ICA inhibited the pathological alterations in liver architecture induced by TAA. The antifibrotic activity of ICA was verified by reduced hepatic collagen deposition in liver sections stained with Masson's trichrome and hepatic Col-1α mRNA and hydroxyproline contents compared to the TAA-treated group. The antiangiogenic activity of ICA was evidenced by lowered levels of mRNA of Ang-1 and protein expression of VEGF, PDGF-β, and CTGF immunohistochemically. Further, the anti-autophagic proper...Continue Reading

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Citations

Aug 5, 2017·International Journal of Molecular Sciences·Woonhyeok JeongWon Jai Lee
Feb 8, 2018·Canadian Journal of Physiology and Pharmacology·Nehal A AfifiMona K Galal
Mar 7, 2019·The Journal of Pharmacology and Experimental Therapeutics·Fa-Ju ChenJing-Shan Shi
Aug 26, 2020·Human & Experimental Toxicology·Ahmed A ElnfarawyRehab S Abdelrahman
Nov 2, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nagla A El-Shitany, Basma G Eid
Oct 2, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Xiaochuan ZhengWenbin Liu
Feb 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Salma M ErakyAmal M El-Gayar

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