Jun 29, 2016

iCAVE: an open source tool for immersive 3D visualization of complex biomolecular interaction networks

BioRxiv : the Preprint Server for Biology
Vaja LiluashviliZeynep H. Gümü?

Abstract

Visualizations of biomolecular networks assist in systems-level data exploration in myriad cellular processes in health and disease. While these networks are increasingly informed by data generated from high-throughout (HT) experiments, current tools do not adequately scale with concomitant increase in their size and complexity. We present an open-source software platform, interactome-CAVE, (iCAVE), that leverages stereoscopic (3D) immersive display technologies for visualizing complex biomolecular interaction networks. Users can explore networks (i) in 3D in any computer and (ii) in immersive 3D in any computer with an appropriate graphics card as well as in CAVE environments. iCAVE includes new 3D network layout algorithms in addition to extensions of known 2D network layout, clustering and edge-bundling algorithms to the 3D space, to assist in understanding the underlying structures in large, dense, layered or clustered networks. Users can perform simultaneous queries of several databases within iCAVE or visualize their own networks (e.g. disease, drug, protein, metabolite, phenotype, genotype) utilizing directionality, weight or other properties by using different property settings. iCAVE has modular structure to allow rapi...Continue Reading

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Mentioned in this Paper

Computer Software
Size
Evac Protocol
Anatomical Layer
Cellular Process
2-Dimensional
Three-dimensional
Complex (molecular entity)
Serotonin
Environment

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