Ichthyosis: A Road Model for Skin Research

Acta Dermato-venereologica
Anders Vahlquist, Hans Törmä

Abstract

The understanding of monogenetic disorders of cornification, including the group of diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of more than 50 types of ichthyosis have almost invariably uncovered errors in the biosynthesis of epidermal lipids or structural proteins essential for normal skin barrier function. The barrier abnormality per se may elicit epidermal inflammation, hyperproliferation and hyperkeratosis, potentially contributing to the patient's skin symptoms. Despite this and other new knowledge about pathomechanisms, treatment of ichthyosis often remains unsatisfactory. This review highlights a series of approaches used to elucidate the pathobiology and clinical consequences of different types of ichthyosis, and related diseases with the ultimate goal of finding new and better treatments.

Citations

Oct 8, 2020·World Journal of Clinical Cases·Ariana S GinsbergJoseph P Terlizzi
Jan 11, 2021·The Journal of Investigative Dermatology·Leila YoussefianJouni Uitto
May 25, 2021·Differentiation; Research in Biological Diversity·Hanqian ZhangHans Törmä

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