Icilin evokes a dose- and time-dependent increase in glutamate within the dorsal striatum of rats

Amino Acids
Jennifer L WerkheiserA Cowan

Abstract

Icilin, the peripheral cold channel agonist, activates TRPM8 and TRPA1, localized on dorsal root ganglia and trigeminal neurons in rats. Icilin precipitates immediate wet-dog shakes in this species, which are antagonized by centrally acting mu and kappa opioid agonists, implicating the central nervous system in the behavioral response. We studied the effect icilin has on glutamate levels in the dorsal striatum, a brain region involved in movement. Icilin (0.25, 0.5 and 0.75 mg/kg, i.p.) elicited a dose- and time-dependent increase in glutamate within the striatum, indicative of icilin's neurochemical effect in rats.

References

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Citations

Aug 4, 2012·ACS Chemical Neuroscience·Sonali S Bharate, Sandip B Bharate
Mar 17, 2012·Bioorganic & Medicinal Chemistry Letters·Jay M MatthewsChristopher M Flores
May 5, 2009·The Journal of Pain : Official Journal of the American Pain Society·Heather L RossiJohn K Neubert
Mar 14, 2009·The Journal of Investigative Dermatology·Ruzanna AtoyanNatalia V Botchkareva
Sep 2, 2006·European Journal of Pharmacology·Jennifer L WerkheiserAlan Cowan
May 8, 2007·Neuron·Raymond W ColburnNing Qin
Feb 16, 2013·Bioorganic & Medicinal Chemistry Letters·Bin ZhuMark J Macielag
Aug 26, 2020·Expert Opinion on Therapeutic Targets·Daniel Souza Monteiro de AraujoFrancesco De Logu

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