Icodextrin with nitroprusside increases ultrafiltration and peritoneal transport during long CAPD dwells

Kidney International
C E DoumaRaymond T Krediet

Abstract

Addition of the nitric oxide (NO) donor nitroprusside to 1.36% glucose dialysate enlarges the effective peritoneal surface area during four-hour dwells. The theoretical positive effect on ultrafiltration is, however, counteracted by an increase in glucose absorption. The absorption of the glucose polymer icodextrin is much lower in comparison with glucose-based dialysis solutions, due to its high molecular weight. In the present study 7.5% icodextrin dialysis solution with and without the addition of 4.5 mg/liter nitroprusside was studied during eight-hour CAPD dwells. Two Standard Peritoneal permeability Analyses, adapted for eight-hour dwells, were performed in 10 stable CAPD patients. Nitrate and cGMP were measured as parameters of NO synthesis. The transcapillary ultrafiltration increased in a linear way with icodextrin (ICO) and was even higher after the addition of nitroprusside (NP): 666 (ICO) versus 834 (NP) ml/8 hr, P = 0.03. The effective lymphatic absorption rate was not different. The resulting net ultrafiltration increased with nitroprusside: 344 (ICO) versus 540 (NP) ml/8 hr, P < 0.01. The mass transfer area coefficient of urea increased 15% and that of creatinine 26% with nitroprusside, consistent with the expect...Continue Reading

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Citations

Apr 5, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhonghua ZhuAnguo Deng
Dec 16, 1998·Kidney International·R T KredietD G Struijk
Sep 17, 2002·Kidney International. Supplement·Raymond Krediet, Salim Mujais
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D S RajJ Work
Oct 30, 1998·The Journal of Laboratory and Clinical Medicine·C E DoumaR T Krediet
Nov 10, 2000·Advances in Renal Replacement Therapy·R T Krediet
Mar 4, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alp AkonurJohn K Leypoldt
Nov 17, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Jacek WaniewskiBengt Lindholm
Oct 25, 2002·Journal of the American Society of Nephrology : JASN·Peter J Margetts, David N Churchill

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