ICOS co-stimulatory receptor is essential for T-cell activation and function

Nature
C DongRichard A Flavell

Abstract

T-lymphocyte activation and immune function are regulated by co-stimulatory molecules. CD28, a receptor for B7 gene products, has a chief role in initiating T-cell immune responses. CTLA4, which binds B7 with a higher affinity, is induced after T-cell activation and is involved in downregulating T-cell responses. The inducible co-stimulatory molecule (ICOS), a third member of the CD28/CTLA4 family, is expressed on activated T cells. Its ligand B7H/B7RP-1 is expressed on B cells and in non-immune tissues after injection of lipopolysaccharide into animals. To understand the role of ICOS in T-cell activation and function, we generated and analysed ICOS-deficient mice. Here we show that T-cell activation and proliferation are defective in the absence of ICOS. In addition, ICOS -/- T cells fail to produce interleukin-4 when differentiated in vitro or when primed in vivo. ICOS is required for humoral immune responses after immunization with several antigens. ICOS-/- mice showed greatly enhanced susceptibility to experimental autoimmune encephalomyelitis, indicating that ICOS has a protective role in inflammatory autoimmune diseases.

References

Nov 11, 1992·European Journal of Immunology·Y LiuP S Linley
May 1, 1995·International Archives of Allergy and Immunology·G Viale, D Vercelli
Sep 1, 1994·International Archives of Allergy and Immunology·T T KungA S Watnick
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Oct 23, 1997·The Journal of Experimental Medicine·W E SuenN H Ruddle
Nov 14, 1997·Immunity·C B Thompson, J P Allison
Dec 16, 1998·Science·C DongR A Flavell
Apr 21, 1999·Current Opinion in Cell Biology·C A Chambers, J P Allison
Jun 22, 1999·Current Opinion in Immunology·M A OosterwegelA H Sharpe
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M GirvinS D Miller
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A E JuedesN H Ruddle
Jan 5, 2000·Nature·S K YoshinagaG Senaldi

❮ Previous
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Citations

Nov 6, 2013·Immunology and Cell Biology·Alvin Pratama, Carola G Vinuesa
Oct 23, 2013·Immunology and Cell Biology·Hai QiJiacong Yan
Feb 8, 2003·Journal of Gastroenterology·Takanori KanaiMamoru Watanabe
Jan 5, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sumit K SubudhiYang-Xin Fu
Jun 2, 2006·Springer Seminars in Immunopathology·Mary K Crow
Jan 29, 2010·Seminars in Immunopathology·Michelle A Linterman, Carola G Vinuesa
Oct 12, 2012·Archives of Dermatological Research·Koichi YanabaShinichi Sato
Apr 8, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lin XingHongyan Zhou
Aug 30, 2008·Surgery Today·Xuan-Chao PanMasatoshi Makuuchi
Jun 9, 2012·Breast Cancer Research and Treatment·Venkataswarup TiriveedhiT Mohanakumar
Oct 7, 2006·Journal of Biomedical Science·Shih-Chang LinChia-Hsi Chan
Apr 17, 2003·Life Sciences·Umberto DianzaniUgo Ramenghi
Jan 22, 2008·Expert Reviews in Molecular Medicine·Meera Ramanujam, Anne Davidson
Mar 22, 2002·Nature Reviews. Immunology·T W MakP S Ohashi
Apr 13, 2010·Cellular & Molecular Immunology·Roza I Nurieva, Yeonseok Chung
Jul 9, 2011·Nature Immunology·Marion Pepper, Marc K Jenkins
Feb 2, 2013·Nature Reviews. Drug Discovery·Sheng YaoLieping Chen
Apr 26, 2008·Nature Reviews. Immunology·Simon FillatreauStephen M Anderton
Mar 26, 2002·Nature Reviews. Immunology·Arlene H Sharpe, Gordon J Freeman
Oct 9, 2013·Nature Reviews. Nephrology·Mandy L FordThomas C Pearson
Sep 11, 2013·Nature Reviews. Rheumatology·William Stohl
Sep 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chrysoula I LiakouPadmanee Sharma
Feb 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hong ChenPadmanee Sharma
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mathieu GigouxWoong-Kyung Suh
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paul L BollykyGerald T Nepom
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dan-Li XieXiao-Ping Zhong
Sep 15, 2009·The Journal of Biological Chemistry·Yongliang ZhangChen Dong
Oct 16, 2012·The Journal of Biological Chemistry·Young Rae JiZae Young Ryoo
Apr 3, 2001·The Journal of Experimental Medicine·S Y TsengH Tsuchiya
Apr 17, 2002·The Journal of Experimental Medicine·Shengdian WangJürgen Bajorath
Jun 18, 2003·The Journal of Experimental Medicine·Xingluo LiuYang Liu
Jun 9, 2004·The Journal of Experimental Medicine·Ann E HermanChristophe Benoist
Jun 7, 2006·The Journal of Experimental Medicine·Jennifer L CannonsPamela L Schwartzberg
Apr 16, 2008·The Journal of Experimental Medicine·Xuexian O YangChen Dong

❮ Previous
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