ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection

European Journal of Immunology
Clare L MarriottDavid R Withers

Abstract

Interactions between ICOS and ICOS ligand (ICOSL) are essential for the development of T follicular helper (Tfh) cells and thus the formation and maintenance of GC reactions. Given the conflicting reports on the requirement of other CD4(+) T-cell populations for ICOS signals, we have employed a range of in vivo approaches to dissect requirements for ICOS signals in mice during an endogenous CD4(+) T-cell response and contrasted this with CD28 signals. Genetic absence of ICOSL only modestly reduced the total number of antigen-specific CD4(+) T cells at the peak of the primary response, but resulted in a severely diminished number of both T central memory and T effector memory cells. Treatment with blocking anti-ICOS mAb during the primary response recapitulated these effects and caused a more substantial reduction than blocking CD28 signals with CTLA4Ig. During the memory phase of the response further signals through ICOS or CD28 were not required for survival. However, upon secondary challenge only Tfh cell expansion remained heavily ICOS-dependent, while CD28 signals were required for optimal expansion of all subsets. These data demonstrate the importance of ICOS signals specifically for memory CD4(+) T-cell formation, while h...Continue Reading

References

Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C B ThompsonC H June
Sep 1, 1994·Immunity·J M GreenC B Thompson
Jan 5, 2000·Nature·S K YoshinagaG Senaldi
May 9, 2001·Nature·A J McAdamA H Sharpe
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hans-Willi MittrückerStefan H E Kaufmann
Jul 17, 2003·The Journal of Clinical Investigation·Hiroshi HaradaMohamed H Sayegh
Jul 24, 2003·Nature Reviews. Immunology·Christopher E Rudd, Helga Schneider
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christian P LarsenRobert J Peach
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabrina M C GaspalPeter J L Lane
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hisaya AkibaKo Okumura
Mar 4, 2006·Science·Jason HatayeMarc K Jenkins
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lukas BossallerKlaus Warnatz
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Modesta P NdejembiDonna L Farber
Apr 11, 2007·The Journal of Experimental Medicine·Jared F PurtonCharles D Surh
Jun 6, 2007·European Journal of Immunology·Simmi MahajanDavid Gray
Sep 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·David A Blair, Leo Lefrançois
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yvonne BurmeisterAndreas Hutloff
Feb 14, 2008·The Journal of Allergy and Clinical Immunology·Flavio Vincenti
Mar 7, 2008·Nature·Laurie E HarringtonCasey T Weaver
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D SchenkA Valujskikh
Apr 18, 2009·Nature Protocols·James J MoonMarc K Jenkins
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naomi TakahashiTomohiro Morio
Feb 2, 2010·Current Opinion in Immunology·Tyler R SimpsonJames P Allison
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Jul 8, 2010·The Journal of Pharmacology and Experimental Therapeutics·Ronald HerbstAnthony J Coyle
Mar 3, 2011·PloS One·Tamson V MooreAnne I Sperling
Jul 27, 2011·The Journal of Experimental Medicine·Fabrina GaspalPeter J L Lane
Aug 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·David R WithersPeter J L Lane
Mar 9, 2013·Nature Reviews. Immunology·Lieping Chen, Dallas B Flies
Oct 9, 2013·Nature Reviews. Nephrology·Mandy L FordThomas C Pearson
Dec 18, 2013·Nature Reviews. Immunology·Donna L FarberNicholas P Restifo
Apr 29, 2014·European Journal of Immunology·Clare L MarriottDavid R Withers

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Citations

Aug 26, 2016·Frontiers in Immunology·Daniel J Wikenheiser, Jason S Stumhofer
Apr 14, 2012·Current Opinion in Cell Biology·Daniel HebenstreitSarah A Teichmann
May 29, 2016·Oncotarget·Terkild Brink BuusJens Peter Holst Lauritsen
Sep 16, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Villegas-MendezKevin N Couper
Jun 24, 2017·The Journal of Experimental Medicine·Antje HeitM Juliana McElrath
Jun 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nanette MitterederGianluca Carlesso
Jun 26, 2020·Frontiers in Physiology·Xue-Ke LiuDuan-Yong Liu

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Methods Mentioned

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flow cytometry
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