ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity

Immunity
Hadi MaaziOmid Akbari

Abstract

Allergic asthma is caused by Th2-cell-type cytokines in response to allergen exposure. Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of immune cells that, along with Th2 cells, contribute to the pathogenesis of asthma by producing copious amounts of IL-5 and IL-13, which cause eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma. ILC2s express ICOS, a T cell costimulatory molecule with a currently unknown function. Here we showed that a lack of ICOS on murine ILC2s and blocking the ICOS:ICOS-ligand interaction in human ILC2s reduced AHR and lung inflammation. ILC2s expressed both ICOS and ICOS-ligand, and the ICOS:ICOS-ligand interaction promoted cytokine production and survival in ILC2s through STAT5 signaling. Thus, ICOS:ICOS-ligand signaling pathway is critically involved in ILC2 function and homeostasis.

References

May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·J TavernierC Oefner
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·M LöhningT Kamradt
Nov 15, 2003·Immunity·Jinfang ZhuWilliam E Paul
Nov 15, 2011·The Journal of Allergy and Clinical Immunology·Jillian L BarlowAndrew N J McKenzie
Nov 29, 2011·The Journal of Allergy and Clinical Immunology·Hye Young KimDale T Umetsu
Nov 24, 2012·The Journal of Allergy and Clinical Immunology·Jerome KerzerhoOmid Akbari
Jan 8, 2013·Nature Reviews. Immunology·Jennifer A WalkerAndrew N J McKenzie
Mar 16, 2013·Current Opinion in Immunology·Thomas HoylerAndreas Diefenbach
May 21, 2013·The Journal of Allergy and Clinical Immunology·Ilkka S JunttilaWilliam E Paul
May 22, 2013·The Journal of Allergy and Clinical Immunology·Taylor A DohertyDavid H Broide
Jun 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Roel G J Klein WolterinkJames P Di Santo
Jul 3, 2013·The Journal of Allergy and Clinical Immunology·Jillian L BarlowAndrew N J McKenzie
Dec 4, 2013·International Archives of Allergy and Immunology·Hee-Kyoo KimTaylor A Doherty
Apr 30, 2014·Blood·Mette D Hazenberg, Hergen Spits
Aug 31, 2014·The Journal of Allergy and Clinical Immunology·Kathleen R BartemesHirohito Kita

❮ Previous
Next ❯

Citations

Jan 21, 2016·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Xiaohan HuXueguang Zhang
Feb 13, 2016·Current Opinion in Immunology·Qi Yang, Avinash Bhandoola
Aug 8, 2015·European Journal of Immunology·Daniela PaclikChiara Romagnani
Aug 27, 2015·International Immunology·Timotheus Y F Halim
Mar 12, 2016·Seminars in Immunopathology·Leonie van RijtRonald van Ree
Jun 7, 2015·Biochemical and Biophysical Research Communications·Fumitaka KamachiSachiko Miyake
Nov 22, 2015·The Journal of Allergy and Clinical Immunology·Yuzo SuzukiOmid Akbari
Feb 19, 2016·European Journal of Immunology·Hye Young KimRosemarie H Dekruyff
Sep 1, 2015·Frontiers in Immunology·Nicole von BurgDaniela Finke
Jun 4, 2016·Cytokine·Claudia U Duerr, Jörg H Fritz
Apr 12, 2016·European Journal of Immunology·Bobby W S LiRudi W Hendriks
Jun 22, 2016·Nature Immunology·Christoph S N Klose, David Artis
Aug 26, 2016·Frontiers in Immunology·Daniel J Wikenheiser, Jason S Stumhofer
Jun 25, 2016·Immunology·David R Withers
May 24, 2011·Pulmonary Pharmacology & Therapeutics·James G Martin, Mauro Novali
Sep 27, 2016·Pulmonary Pharmacology & Therapeutics·Jatinder SinghDhandeep Singh
Aug 6, 2016·The Journal of Allergy and Clinical Immunology·Kristina JohanssonMadeleine Rådinger
Oct 19, 2016·Nature Communications·Lauriane Galle-TregerOmid Akbari
Nov 8, 2016·The Journal of Allergy and Clinical Immunology·Hideaki MoritaShigeo Koyasu
Jan 15, 2017·The Journal of Allergy and Clinical Immunology·Taylor A Doherty, David H Broide
May 19, 2017·The Journal of Experimental Medicine·Laura Chiossone, Eric Vivier
Jun 6, 2017·The Journal of Allergy and Clinical Immunology·Hadi MaaziOmid Akbari
Jun 29, 2017·Immunological Reviews·Hadi Maazi, Omid Akbari
Jun 29, 2017·Immunological Reviews·Kafi N EaleyShigeo Koyasu
Apr 7, 2018·Seminars in Immunopathology·Markus KindermannStefan Wirtz
Mar 2, 2018·Annals of the New York Academy of Sciences·Martijn J Schuijs, Timotheus Y F Halim
Feb 6, 2018·Current Pharmacology Reports·Everett K HenryMark C Siracusa
Nov 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathleen BartemesHirohito Kita
Dec 7, 2017·Oncoimmunology·Mariona CaboLorenzo Galluzzi
Dec 19, 2017·Frontiers in Immunology·Bobby W S LiRudi W Hendriks
Aug 30, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Jian Li, Sarah C Glover
Sep 14, 2018·Nature Reviews. Immunology·Laura ChiossoneEric Vivier
Dec 6, 2018·Current Opinion in Allergy and Clinical Immunology·Anne-Charlotte JonckheereSven F Seys
Jan 22, 2019·Mucosal Immunology·Malcolm R StarkeyPhilip M Hansbro
Jan 17, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hillary L ShaneStacey E Anderson
Feb 12, 2019·Annual Review of Physiology·Jillian L Barlow, Andrew N J McKenzie
Jan 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryuichi NagashimaNobuyuki Tanaka
Jan 24, 2019·Current Opinion in Allergy and Clinical Immunology·Juan M Inclan-RicoMark C Siracusa
Jan 27, 2019·The Journal of Pathology·Guy J M CameronMalcolm R Starkey
Feb 23, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Alberta G A PaulJudith A Woodfolk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis