Icotinib in Patients with Pretreated Advanced Esophageal Squamous Cell Carcinoma with EGFR Overexpression or EGFR Gene Amplification: A Single-Arm, Multicenter Phase 2 Study

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Jing HuangYan Sun

Abstract

Epidermal growth factor receptor (EGFR) has been reported to be overexpressed and amplified in a high percentage of patients with esophageal squamous cell carcinoma (ESCC). The activity of icotinib, an EGFR tyrosine kinase inhibitor, was assessed in previously treated ESCC with EGFR overexpression or amplification. For this phase 2, single-arm, multicenter trial undertaken at six hospitals in China, we included Chinese patients with previously treated, histologically confirmed advanced ESCC and EGFR overexpression (immunohistochemical staining sore of 3+) or amplification (positive fluorescence in situ hybridization result). These patients received oral icotinib (250 mg, three times daily).The primary end point was the proportion of patients with objective responses as assessed by an independent radiology review committee. Between December 5, 2013, and May 28, 2015, a total of 281 patients were screened. Fifty-four eligible patients were enrolled. Nine responses were observed, including one complete response and eight partial responses, and 16 patients had stable disease, resulting in a 16.7% objective response rate (95% confidence interval [CI]: 6.7-26.6) and 46.3% disease control rate (95% CI: 33.0-59.6). The median progressi...Continue Reading

References

Jul 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H BleibergT Sahmoud
Sep 15, 2005·International Journal of Cancer. Journal International Du Cancer·Mitsuhiko HanawaAkishi Ooi
Nov 22, 2005·Journal of Surgical Oncology·Manuel PeraLuis Grande
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maarten L JanmaatGiuseppe Giaccone
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David R FerryJanusz Jankowski
Nov 25, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fenlai TanYinxiang Wang
Feb 22, 2013·International Journal of Oncology·Hiroaki KatoKazuto Nishio
Nov 10, 2013·Nature Medicine·Curtis R Chong, Pasi A Jänne
Aug 6, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christiane D FichterSilke Lassmann
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray

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Citations

Aug 28, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Annikka WeissferdtCesar A Moran
Feb 15, 2017·Nature Reviews. Clinical Oncology·Qing ZhouYi-Long Wu
Feb 20, 2018·Molecular Cancer·Manoj Kumar Kashyap, Omar Abdel-Rahman
Jan 15, 2020·Anti-cancer Drugs·Qian ZhaoShengjiang Guan
May 26, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Russell D PettyZosia Miedzybrodzka
Sep 23, 2020·British Journal of Cancer·Mark A BaxterRussell D Petty
Oct 9, 2020·Signal Transduction and Targeted Therapy·Yan-Ming YangBin Li
Nov 30, 2019·Cancer Discovery·Thomas L ClarkeJohnathan R Whetstine
Jan 24, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jing HuangYuchen Jiao
Jan 25, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexa B SchrockVincent A Miller
Jan 1, 2021·Histopathology·Matthew W Rosenbaum, Raul S Gonzalez
Dec 29, 2020·Frontiers in Oncology·Steven B MaronYelena Y Janjigian
May 8, 2021·Critical Reviews in Oncology/hematology·Renu VermaSundeep Singh Saluja
Feb 6, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Simona CorsoSilvia Giordano
May 27, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H S AbboudS C Soares-Lima

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