ICRF 187 and polyhydroxyphenyl derivatives fail to protect against bleomycin induced lung injury.

Toxicology
A F Tryka

Abstract

The potential protective effects of ICRF 187, Didox, Amidox and VF 165 were investigated in models of bleomycin, or bleomycin and hyperoxia induced lung injury. ICRF 187, a bispiperazinedione compound, is a strong chelating agent which blocks a number of free radical mediated processes. The polyhydroxyphenyl derivatives, Didox, Amidox and VF 165, demonstrate degrees of Fe chelating activities and free radical scavenging abilities. Hamsters treated with 5.0 U/kg bleomycin followed by treatment with ICRF 187 or Didox exhibited similar mortality to the bleomycin alone treated group. In a second study, a low dose of bleomycin (1.2 U/kg) was used followed by exposure to 70% oxygen. Treatment with ICRF 187, Didox, Amidox, or VF 165 failed to protect against lung injury; with the ICRF 187 and Amidox groups exhibiting significantly increased rates of mortality over that seen in animals treated only with bleomycin and hyperoxia. No animals treated with the agents alone died. Histopathology documented that all bleomycin-treated hamsters died of severe pneumonitis. Additionally, in the agent-treated groups there was a prominent proliferation of type II pneumocytes, which demonstrated marked anaplasia, a feature not typical of early bleomy...Continue Reading

References

Aug 1, 1986·Toxicology and Applied Pharmacology·R C LindenschmidtH Witschi
Oct 1, 1986·Biochemical Medicine and Metabolic Biology·S N GiriB J Marafino
Apr 26, 1969·Nature·A M CreightonS Whitecross
Nov 1, 1983·Experimental Lung Research·A F TrykaJ D Brain

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