Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy

Epilepsy Research
S A ParkByung In Lee

Abstract

To characterize ictal electrocorticographic features related to surgical outcomes in nonlesional neocortical epilepsy (NE). We analyzed 187 ictal electrocorticograms (ECoG) obtained from 18 patients who had undergone presurgical evaluation and subsequent neocortical resections (frontal: seven, parietal: one, occipital: four, multilobar: six). None of them had any MRI-detectable lesions. Various ECoG data sets recorded from eight patients who achieved a favorable surgical outcome (either seizure free or more than 90% reduction of seizure frequencies) were compared with that from ten patients with unfavorable outcome (less than 90% reduction of seizure frequencies) (follow up duration: 47+/-11 months). Reproducible ictal onset zone (IOZ) in recurrent seizures (P=0.013) and persistent ictal discharges in IOZ from the onset to the end of seizure (P=0.004) were found more frequently in the patients with good outcome. Ictal onset patterns consisting of low voltage fast or high amplitude beta spikes predicted a good surgical outcome while rhythmic sinusoidal activity or rhythmic spike/sharp waves of slow frequency were predictive of poor outcome (P=0.01). The ictal onset rhythm consisting of gamma or beta frequencies was more prevalen...Continue Reading

References

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Citations

Jun 5, 2013·JAMA Neurology·Katherine NoeGregory A Worrell
Jun 27, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Joong-Uhn Choi
Jan 19, 2006·Epilepsia·Leo H BonatiStephan Ruegg
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May 5, 2017·PLoS Computational Biology·Yujiang WangMarcus Kaiser
Jun 25, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroshi ShirozuShigeki Kameyama
May 11, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paolo BazzigaluppiBojana Stefanovic

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