PMID: 8584760Oct 20, 1995Paper

ICV administration of anti-corticotropin-releasing factor antisense oligonucleotide: effects on feeding behavior and body weight

Regulatory Peptides
M G HulseyR J Martin

Abstract

Corticotropin-releasing factor (CRF) has been reported to reduce food intake and body weight, and numerous studies suggest a role for CRF in putative mechanisms for the regulation of body energy. This study investigated the effects of ICV-administered antisense phosphorothioate oligonucleotides, directed against the CRF mRNA, on feeding behavior and body weight in rats. Sixteen male HSD rats were cannulated in the lateral ventricle, and given ad libitum access to tap water and a ground chow diet. Feeding behavior was recorded by computer, and meal patterns were assessed. Rats were given 3 micrograms each of two anti-CRF oligonucleotides (aCRF) or two control oligos in the hour before the onset of the nocturnal cycle for ten consecutive days. Cumulative food intake was assessed at 3, 6, 12 and 24 h after each injection, as well as over the 10-day injection period. Compared to missense controls, rats receiving the antisense oligonucleotides ate significantly more at 6 h (P = 0.01), but not at 3, 12, 24 h, or during the entire 10-day injection period (P > 0.05). There was no effect on body weight change, meal size, or meal interval (P > 0.05). These data indicate that daily administration of anti-CRF oligonucleotides has a signifi...Continue Reading

References

Dec 1, 1992·Physiology & Behavior·M G Hulsey, R J Martin
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·S C HeinrichsG F Koob
Aug 1, 1991·Physiology & Behavior·M G Hulsey, R J Martin
Jul 1, 1990·Brain Research Bulletin·S Rivest, D Richard
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·N J Rothwell
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A JaegerM Zuker
Mar 1, 1989·Physiology & Behavior·K AraseG A Bray
Feb 1, 1986·Neuropeptides·A V VergoniA Bertolini
May 1, 1987·Molecular Endocrinology·R C ThompsonE Herbert
Feb 1, 1994·Trends in Neurosciences·M HeiligK T Britton
Oct 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T SkutellaG F Jirikowski
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·E PotterW Vale
Oct 29, 1993·Annals of the New York Academy of Sciences·D Richard
Mar 1, 1993·Physiology & Behavior·N De PedroM Alonso-Bedate

❮ Previous
Next ❯

Citations

Apr 30, 1999·Journal of Psychiatric Research·R K StøvingC Hagen
Jan 1, 1997·Annual Review of Nutrition·A S Levine, C J Billington
Sep 1, 2009·The Journal of Nutritional Biochemistry·Sami Dridi, Mohammed Taouis
Jun 8, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·R K StøvingC Hagen
Aug 29, 2006·Neuropeptides·Sarika Arora, Anubhuti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.