Abstract
Accumulating evidence reveals that Id-1 is upregulated and functions as a potential tumor promoter in several human cancer types. However, the role of Id-1 in osteosarcoma (OS) is unknown. In present study, we found that Id-1 expression was elevated in OS tissues than adjacent normal bone tissues. More importantly, we demonstrated that overexpression of Id-1 is significantly correlated with tumor progression and poor survival in OS patients. Furthermore, increased expression of Id-1 was observed in OS cell lines and ectopic expression of Id-1 significantly enhanced in vitro cell proliferation and promoted in vivo tumor growth, whereas knockdown of Id-1 suppressed OS cells growth. Moreover, our experimental data revealed that Id-1 promotes cell proliferation by facilitating cell cycle progression and inhibits cell apoptosis. Mechanistically, the effects of Id-1 in OS cells is at least partly through activation of PI3K/Akt signaling pathway. Therefore, we identified a tumorigenic role of Id-1 in OS and suggested a potential therapeutic target for OS patients.
References
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan S BielackKurt Winkler
Jul 26, 2003·Oncogene·Ming-Tat LingYong-Chuan Wong
Sep 2, 2003·Carcinogenesis·Terence Kin-Wah LeeSheung-Tat Fan
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A MeyersHolcombe Grier
Jul 22, 2005·Nature Reviews. Cancer·Jonathan PerkRobert Benezra
Sep 4, 2008·British Journal of Cancer·D WangsaE Munck-Wikland
Oct 17, 2008·Cancer Research·Yuji KashiwakuraHiromi Kumon
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Bin LiAnnie L M Cheung
Mar 11, 2010·Current Pharmaceutical Design·Amancio Carnero
Jun 25, 2010·Cancer Biology & Therapy·Rui DingKefeng Dou
Dec 16, 2010·Cancer Cell·Judit AnidoJoan Seoane
May 12, 2011·Sarcoma·Matthew L BroadheadPeter F M Choong
May 25, 2011·Molecular and Cellular Biology·Smitha PillaiSrikumar Chellappan
Jan 10, 2012·Urologic Oncology·Hao HuKe Xin Xu
May 15, 2012·Oncogene·K AhlqvistR Massoumi
Dec 18, 2012·Cancer Research·Liliana SoroceanuSean D McAllister
Jul 3, 2013·Oncogene·L LiuD Wu
Mar 26, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yue TengXu Li
Mar 3, 2015·Biochemical and Biophysical Research Communications·Yuanmin ZhangShiqing Feng
Sep 26, 2015·Cellular Signalling·Gabriela Nestal de MoraesRaquel C Maia
Citations
Dec 14, 2017·Journal of Biomedical Science·Jie LiPing Chen
Nov 18, 2018·Bioscience Reports·Bin LiuJian-Min Li
Feb 19, 2020·Journal of Tissue Engineering and Regenerative Medicine·Luis PadillaPaul Mondragón-Terán
Apr 24, 2020·Molecular Medicine Reports·Yu-Bin QiLin Nie
Mar 20, 2019·The Kaohsiung Journal of Medical Sciences·Xue-Liang WuGuang-Yuan Sun
Apr 20, 2019·Journal of Cellular Physiology·Meihan LiuWenjun Wang
Mar 18, 2021·Future Oncology·Quan ZhouYa-Ling Tao
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bo ZhangXiao-Rui Yu